Evidence map›Paper›PMID 41393105›Full record

ArticleJournal of biomedical optics2025

Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.

Justin Schumacher, Christian Zevallos-Delgado, Leana Rohman, Alexander W Schill, Manmohan Singh, Hongyuan Zhang, Marco Ruggeri, Jean-Marie Parel, Fabrice Manns, Kirill V Larin and 1 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  2. Article
  3. Editorial: Advances in Optical Elastography.Journal of biomedical optics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Justin SchumacherUniversity of Maryland, Department of Bioengineering, College Park, Maryland, United States.
Christian Zevallos-DelgadoUniversity of Houston, Department of Biomedical Engineering, Houston, Texas, United States.ORCID https://orcid.org/0000-0001-7078-3782
Leana RohmanUniversity of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States.
Alexander W SchillUniversity of Houston, Department of Biomedical Engineering, Houston, Texas, United States.
Manmohan SinghUniversity of Houston, Department of Biomedical Engineering, Houston, Texas, United States.ORCID https://orcid.org/0000-0002-8396-5451
Hongyuan ZhangCole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.ORCID https://orcid.org/0000-0002-4949-6882
Marco RuggeriUniversity of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States.
Jean-Marie ParelUniversity of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States.
Fabrice MannsUniversity of Miami, Department of Biomedical Engineering, Coral Gables, Florida, United States.
Kirill V LarinUniversity of Houston, Department of Biomedical Engineering, Houston, Texas, United States.ORCID https://orcid.org/0000-0002-5532-5027
Giuliano ScarcelliUniversity of Maryland, Department of Bioengineering, College Park, Maryland, United States.ORCID https://orcid.org/0000-0002-1736-077X

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI GEUNYOUNG YOON · 1988 to 2026
$16.4M
Cornea biomechanical analysis with Brillouin microscopyR01EY028666 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI James Bradley Randleman, Giuliano Scarcelli · 2018 to 2026
$4.1M
Biomechanics of accommodationR01EY030063 · NEI · UNIVERSITY OF HOUSTON · PI LARIN, KIRILL V, MANNS, FABRICE · 2020 to 2024
$3.0M
Determining the Efficacy of Corneal Cross-Linking Protocols using Brillouin MicroscopyR01EY032537 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI DUPPS, WILLIAM JOSEPH, RANDLEMAN, JAMES BRADLEY · 2022 to 2025
$1.6M
Combining OCE and Brillouin microscopy to evaluate in vivo lens biomechanics in PresbyopiaF30EY035154 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Justin Scott Schumacher · 2024 to 2026
$144k
NEI NIH HHS F30 EY035154NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY028666NEI NIH HHS R01 EY030063NEI NIH HHS R01 EY032537
6 · The paper itself

Abstract

Significance: Estimating biomechanical properties of the Aim: We aim to develop a multimodal elastography device that enables high-performance sequential 3D imaging with both Brillouin microscopy and optical coherence elastography (OCE). Approach: We combined Brillouin spectroscopy and OCE on a modified slit lamp platform for human measurements. The multimodal system was first characterized and then tested on both a porcine eye and a human subject. Results: Both OCE and Brillouin microscopy were characterized at peak operating performance for clinical imaging. Successful measurements of an Conclusion: We demonstrated the first successful multimodal OCE and Brillouin microscopy measurement in a human subject. This instrument offers the potential to characterize the biomechanical status of presbyopia with age.

Indexed as

Elasticity Imaging TechniquesLens, CrystallineMicroscopyMultimodal ImagingTomography, Optical CoherenceAnimalsBiomechanical PhenomenaEquipment DesignHumansImaging, Three-DimensionalPresbyopiaSwineBrillouin microscopyophthalmic instrumentationoptical coherence elastographyoptical coherence tomographyopticspresbyopia

Identifiers

PMID41393105
PMCPMC12700446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.