Evidence map›Paper›PMID 41393099›Full record

ArticleJournal of sickle cell disease2025

International variations in body mass index within the CASiRe global cohort of sickle cell disease patients.

Crawford Strunk, Angela Rivers, Catherine Segbefia, Raffaella Colombatti, Immacolata Tartaglione, Deepa Manwani, Eugenia Vicky Asare, Connie M Piccone, Donna Boruchov, William T Zempsky and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sickle cell disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Crawford StrunkPediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic, Cleveland, OH, 44195, United States.ORCID https://orcid.org/0000-0003-1954-2929
Angela RiversDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, 94609, United States.
Catherine SegbefiaDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.ORCID https://orcid.org/0009-0007-4030-418X
Raffaella ColombattiDepartment of Women's and Child's Health, University of Padova, Padova, 35138, Italy.ORCID https://orcid.org/0000-0001-9797-0457
Immacolata TartaglioneDepartment of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, 80138, Italy.ORCID https://orcid.org/0000-0003-1278-2372
Deepa ManwaniDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, 38105, United States.ORCID https://orcid.org/0000-0003-1057-1811
Eugenia Vicky AsareDepartment of Hematology, Korle-Bu Teaching Hospital, Accra, GA-221-1570, Ghana.ORCID https://orcid.org/0000-0002-7931-391X
Connie M PicconePediatric Hematology/Oncology, Rainbow Babies and Children's Hospital, Cleveland, OH, 44106, United States.ORCID https://orcid.org/0000-0002-7435-2346
Donna BoruchovDepartment of Pediatrics, Connecticut Children's Medical Center, Hartford, CT, 06106, United States.ORCID https://orcid.org/0000-0002-2959-5787
William T ZempskyDepartment of Pediatrics, Connecticut Children's Medical Center, Hartford, CT, 06106, United States.ORCID https://orcid.org/0000-0001-7162-0002
Gifty Dankwah BoatemaaDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0009-0002-0594-6391
Sudha Mahesh Ramachandra RaoDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.ORCID https://orcid.org/0009-0001-4727-1858
Sophia AkatueDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0009-0001-2864-1139
Bianca OtengDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0009-0000-0436-2242
Ahmed OwdaDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0000-0001-6764-7333
Rose BamfoDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0009-0002-7046-1104
Samuel R WilsonDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0000-0001-6517-0076
Fatimah FarooqDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0000-0003-3272-1032
Rebekah UrbonyaDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0000-0002-6024-6040
John BarberDivision of Biostatistics and Study Methodology, Children's National Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC, 20037, United States.ORCID https://orcid.org/0000-0002-0192-5545
Fredericka SeyGhana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, GA-221-1570, Ghana.
Baba InusaDepartment of Pediatric Haematology, Evelina Children's Hospital, Guy's and St. Thomas NHS Trust, London, 2E17EH, United Kingdom.ORCID https://orcid.org/0000-0003-2643-765X
Charles Antwi-BoasiakoDepartment of Physiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-2750-3500
Biree AndemariamDivision of Hematology-Oncology, New England Sickle Cell Institute, Neag Comprehensive Cancer Center, University of Connecticut, Farmington, CT, 06030, United States.ORCID https://orcid.org/0000-0002-2540-6037
Andrew D CampbellDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI, 48109, United States.ORCID https://orcid.org/0000-0002-8829-0043

Funding

University of Michigan Minority Health and Health Disparities International Research Training ProgramT37MD001425 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOULTON, MATTHEW LESTER · 2005 to 2025
$4.8M
NIMHD NIH HHS T37 MD001425
6 · The paper itself

Abstract

Objectives: Although SCD has traditionally been associated with underweight status, body mass index (BMI) status is shifting globally. As disease-modifying therapies have become available, BMI status has increased. Our aim was to determine the prevalence and risk factors of underweight, overweight, and obese statuses in SCD patients in low-middle and high-income countries. Methods: The CASiRe research consortium cross-sectionally analyzed the association of BMI status (underweight, normal weight, overweight, and obesity) to age, genotype, treatment status, and associated clinical outcomes of 532 SCD patients from Italy, United States, and Ghana. Results: Overall, BMI status varied significantly between countries (underweight Conclusions: As access to disease-modifying therapy improves for SCD, monitoring for overweight and obesity and their comorbid conditions may be necessary. Underweight SCD patients should be carefully evaluated for end-organ complications, especially in low-resource settings.

Indexed as

body mass indexglobalobesitySCDunderweight

Identifiers

PMID41393099
PMCPMC12701789

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.