Evidence map›Paper›PMID 41393061›Full record

ArticleSAGE open medical case reports2025

Dramatic clearance of extensive psoriasis in a pediatric patient treated with upadacitinib: A case report.

Jenna Mistry, Michal Moshkovich, Maxwell Sauder, Cathryn Sibbald

Abstract readCase Reports
In one paragraph

Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jenna MistryTemerty Faculty of Medicine, University of Toronto, ON, Canada.
Michal MoshkovichTemerty Faculty of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0009-0001-7612-3950
Maxwell SauderPrincess Margaret Hospital Cancer Centre, Toronto, ON, Canada.
Cathryn SibbaldDivision of Dermatology, Department of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-9288-1121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a unique case of an 8-year-old boy with severe, treatment-refractory palmoplantar psoriasis and genital involvement, unresponsive to nine systemic agents, including multiple biologics and TYK2 inhibition with deucravacitinib. Following years of debilitating symptoms and functional impairment, he achieved near-complete resolution within 2 weeks of initiating upadacitinib monotherapy. This dramatic and sustained response highlights the potential role of JAK1 inhibition in modulating complex inflammatory pathways in pediatric psoriasis, particularly in challenging anatomic sites and refractory cases.

Indexed as

atopic dermatitisJAK inhibitorspediatricpsoriasisupadacitinib

Identifiers

PMID41393061
PMCPMC12698987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.