ArticleFrontiers in public health2025
Association of urinary heavy metals with chronic pain depression co-morbidity: based on NHANES.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Introduction: Accumulating evidence indicates that environmental exposure to toxic metals poses significant risks to human health, yet limited evidence exists regarding the neuropsychiatric effects of mixed metal exposure, particularly in the context of pain-depression co-morbidity (PDC). Methods: To address this gap, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) to evaluate individual and synergistic associations between 12 urinary metals and PDC risk using multi-variable logistic regression, restricted cubic spline (RCS) analysis, and Bayesian kernel machine regression (BKMR). Results: This cross-sectional study of 1,202 participants identified a PDC prevalence of 12.4% ( Discussion: These results advance our understanding of metal-induced neuropsychiatric pathophysiology and support the integration of metal exposure screening into clinical assessments of affective-somatic disorders.
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