Evidence map›Paper›PMID 41392873›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Changes in symptoms and fibroid characteristics in women treated with ultrasound-guided high intensity focused ultrasound (USgHIFU) at Chris Hani Baragwanath Academic Hospital.

Raphaela Setzen, Raymond Setzen, Claire O'Donoghue, Nico Van Dyk, Ayanda Sengane, Nomvuyo Manyatsi, Shalya Sarubdeo, Yasmin Adam

Abstract read
In one paragraph

Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Raphaela SetzenDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Raymond SetzenDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Claire O'DonoghueDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Nico Van DykDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Ayanda SenganeDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Nomvuyo ManyatsiDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Shalya SarubdeoDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.
Yasmin AdamDepartment of Obstetrics & Gynecology, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-3185-8264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe main objective was to describe women with fibroids who were treated with ultrasound-guided high intensity focused ultrasound (USgHIFU) at the Chris Hani Baragwanath Academic Hospital (CHBAH) and to evaluate the outcomes at least 6 months after treatment.

methodsThis was a cross-sectional study using retrospectively collected data of women treated between November 2015 and December 2018 with USgHIFU at CHBAH. A clinical database that was used at the USgHIFU clinic and medical files were reviewed. The following data were retrieved; demographic information, characteristics of the fibroid (size, number, position, magnetic resonance imaging [MRI] intensity), symptoms before and after the procedure. Variables are described using descriptive statistics and were compared using a McNemar's chi2, t-test or Wilcoxon sign rank test.

resultsThe mean age, median body mass index (BMI) and median parity was 35 years (standard deviation [SD] ±5.43), BMI of 25.3 (interquartile range [IQR]: 22.31-29.05), parity 0 (IQR: 0-1; range: 0-6), respectively. The presenting symptoms were dysmenorrhea (85.41%), infertility (50.92%) and menorrhagia (67.69%). The proportion of dysmenorrhea decreased from 84.10% before treatment to 54.06% after treatment. Menorrhagia was reduced from 66.08% to 41.34%. The median size of fibroids changed from 38.00 to 26.88 cm

conclusionThis is the first USgHIFU study that reports outcomes in a South African population. The treatment has resulted in a noticeable alleviation of symptoms and a measurable reduction in fibroid size and this was statistically significant and clinically relevant.

Indexed as

High-Intensity Focused Ultrasound AblationLeiomyomaUterine NeoplasmsAcademic Medical CentersAdultCross-Sectional StudiesFemaleHumansMiddle AgedRetrospective StudiesSouth AfricaTreatment OutcomeUltrasonography, InterventionalfibroidsHIFUSouth AfricaUSgHIFU

Identifiers

PMID41392873
PMCPMC13173625

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.