Evidence map›Paper›PMID 41392804›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Hydrogel Microneedle Array-Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds.

Md Sharifuzzaman, Gauri Hasabnis, Sheikh Ahmed Abu Saleh, Leonard Siebert, Jan-Bernd Hövener, Gregor Maschkowitz, Zeynep Altintas

Abstract read
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In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md SharifuzzamanChair for Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.
Gauri HasabnisChair for Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.
Sheikh Ahmed Abu SalehChair for Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.
Leonard SiebertChair for Functional Nanomaterials, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.
Jan-Bernd HövenerSection Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, 24118, Kiel, Germany.
Gregor MaschkowitzInstitute for Infection Medicine, Kiel University, Brunswiker Str. 4, 24105, Kiel, Germany.
Zeynep AltintasChair for Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.ORCID https://orcid.org/0000-0002-5461-3289

Funding

Aventis Foundation 80304368
6 · The paper itself

Abstract

Topical chronic wound dressings offer personalized management but have limited efficacy in sensing and delivering therapeutics due to their reliance on the wound surface. Herein, a theranostic hydrogel-forming microneedles (HFMNs) dressing system is developed that penetrates the epidermis to continuously sample dermal wound interstitial fluid (ISF), providing high-fidelity diagnostics and active therapy. The dressing is fabricated from a polyvinyl alcohol/chitosan hydrogel incorporating MXene for intrinsic antibacterial and pro-healing properties. Central to the platform's design is a laser-scribed phase separation process that converts a poly(3,4-ethylenedioxythiophene): polystyrene sulfate/graphene oxide coating into highly conductive (384 S/m) and water-stable electrodes directly on the HFMNs. This enables a multiplexed, replaceable array for continuously monitoring seven key wound biomarkers: glucose, uric acid, Na⁺, K⁺, Cl

Indexed as

BandagesHydrogelsNeedlesWounds and InjuriesAnimalsChronic DiseaseEscherichia coliGraphiteHumansMaleRatsRats, Sprague-DawleyStaphylococcus aureusWound Healinggraphene oxideGraphiteHydrogelschronic woundsconductive hydrogel‐forming microneedles arraycorrelation between wound exudate and interstitial fluiddiagnostics and therapylaser‐scribed phase separationtransdermal dressing

Identifiers

PMID41392804
PMCPMC12910427

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.