Evidence map›Paper›PMID 41392517›Full record

ArticleArthritis care & research2026

Temporal Trends and Short- and Long-Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study.

Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas

Abstract read
In one paragraph

Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan ButlerKeele University, Keele, United Kingdom.
Nicholas WeightKeele University, Keele, United Kingdom.ORCID https://orcid.org/0000-0001-5952-7542
Muhammad RashidKeele University, Keele, United Kingdom.
Rodrigo BagurWestern University, London, Ontario, Canada.
Purvi ParwaniLoma Linda University Health, Loma Linda, California.
Samantha HiderKeele University, Keele, United Kingdom.
Edward RoddyKeele University, Keele, United Kingdom.ORCID https://orcid.org/0000-0002-8954-7082
Robert ButlerRoyal Stoke University Hospital, University Hospitals North Midlands, Stoke-On-Trent, United Kingdom.
Mamas A MamasKeele University, Keele, United Kingdom.

Funding

Academy of Medical Sciences SGL025/1064Birmingham Biomedical Research Centre
6 · The paper itself

Abstract

objectiveWe investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long-term mortality post-AMI.

methodsWe analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia National Audit Project registry, linked with Office for National Statistics mortality data and hospital episode statistics. Cox regression models were used to compare risk of all-cause mortality at different time points according to the presence of RA.

resultsThere was no difference in adjusted 30-day mortality between groups (adjusted hazard ratio [aHR] 1.09, 95% confidence interval [CI] 0.99-1.19; P = 0.075). Beyond this, at 1 year (aHR 1.14, 95% CI 1.07-1.21), 5 years, (aHR 1.28, 95% CI 1.23-1.33), and to the end of the study period (aHR 1.31, 95% CI 1.26-1.36), the risk of all-cause mortality was significantly higher in patients with RA (all P < 0.001). Risk of cardiovascular mortality was not significantly different at 30 days or 1 year (aHR 1.08, 95% CI 1.00-1.17; P = 0.058), but it was at 5 years (aHR 1.15, 95% CI 1.08-1.23; P < 0.001) and to the study endpoint post-AMI (aHR 1.18, 95% CI 1.11-1.24; P < 0.001).

conclusionWe found no meaningful disparities in inpatient care according to the presence of RA; however, those with RA have elevated long-term all-cause mortality post-AMI. Our findings suggest that the mortality burden of RA post-AMI is not driven by the quality of AMI care during admission and is likely driven by the progressive nature of the comorbidities and the complications of treatments associated with RA.

Indexed as

Arthritis, RheumatoidMyocardial InfarctionAdultAgedAged, 80 and overCause of DeathCohort StudiesEnglandFemaleHospitalizationHumansMaleMiddle AgedRegistriesRisk AssessmentRisk Factors

Identifiers

PMID41392517
PMCPMC13313107

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.