Evidence map›Paper›PMID 41392458›Full record

ArticleJournal of the American Chemical Society2025

Controlled Self-Immolative Release of β-Lapachone via an Optimized

Julie B Becher, Nisita Dutta, Claudio D Navo, Lavinia Dunsmore, Roman Misteli, Enrique Gil de Montes, Grant G Simpson, Christine C Alewine, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie B BecherYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0002-8417-4475
Nisita DuttaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0002-6497-4053
Claudio D NavoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio 48160, Spain.ORCID 0000-0003-0161-412X
Lavinia DunsmoreYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Roman MisteliYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Enrique Gil de MontesYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Grant G SimpsonYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0003-1693-7060
Christine C AlewineLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0003-1661-0957
Gonzalo Jiménez-OsésCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio 48160, Spain.ORCID 0000-0003-0105-4337
Gonçalo J L BernardesYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0001-6594-8917

Funding

Precision Therapy to Target Pancreatic Ductal AdenocarcinomaZIABC011652 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALEWINE, CHRISTINE · 2015 to 2025
$7.9M
Intramural NIH HHS ZIA BC011652
6 · The paper itself

Abstract

Methodologies to target cancer cells without affecting healthy surrounding cells have the potential to vastly improve both patient outcomes and quality of life.

Indexed as

Antineoplastic AgentsNaphthoquinonesPancreatic NeoplasmsProdrugsCell Line, TumorDrug LiberationHumansTumor MicroenvironmentAntineoplastic Agentsbeta-lapachoneNaphthoquinonesProdrugs

Identifiers

PMID41392458
PMCPMC12766730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.