Evidence map›Paper›PMID 41392323›Full record

ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2026

The Silent Cost of Gender in Mitral Valve Surgery: A Propensity-Score Matched Analysis.

Leo Pölzl, Ronja Lohmann, Clemens Engler, Maria Ioannou-Nikolaidou, Felix Nägele, Jakob Hirsch, Michael Graber, Vanessa Heim, Sophia Schmidt, Ludwig Müller and 6 more

Abstract read
In one paragraph

Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Leo PölzlDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-6552-8899
Ronja LohmannDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Clemens EnglerDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-7808-1336
Maria Ioannou-NikolaidouDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Felix NägeleDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9178-2460
Jakob HirschDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Michael GraberDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-2150-5473
Vanessa HeimDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Sophia SchmidtDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Ludwig MüllerDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Daniel HöferDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Johannes HolfeldDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Lena TschidererInstitute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-7988-853X
Michael GrimmDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Nikolaos BonarosDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Can Gollmann-TepeköylüDepartment of Cardiac Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6584-3488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMitral valve (MV) disease shows sex-specific differences in morphology and outcomes. Women often present later, undergo replacement more frequently, and experience worse survival. This study investigated sex-related disparities in surgical approach, repair rates, and outcomes of MV surgery.

methodsA total of 1531 consecutive patients undergoing MV surgery with or without concomitant tricuspid valve procedure were analysed retrospectively. Baseline characteristics, operative strategies, and outcomes were compared between sexes. Propensity score matching was used to adjust for baseline differences. Primary outcomes were 30-day and 5-year mortality. Baseline and procedural characteristics, including morphology, repair rates, use of minimally invasive MV surgery (MIMVS), and concomitant tricuspid disease, were compared between groups.

resultsFemale patients (44%) were older (68 vs 62 years, P < .001), more symptomatic (New York Heart Association [NYHA] III: 60% vs 46%, P < .001), and more likely to have annular calcification (15% vs 5%, P < .001) or concomitant tricuspid disease (25% vs 36%, P < .001). Carpentier type IIIa was more prevalent in women (21% vs 4%), while type II predominated in men (75% vs 49%). MIMVS and repair were less frequent in women (49% vs 65% and 67% vs 85%, both P < .001). Female sex was associated with increased 30-day (HR 4.07, 95% CI 1.51-11.0; P = .006) and 5-year mortality (HR 1.58, 1.02-2.46; P = .043). After adjusting for morphology and calcification, sex was no longer an independent predictor of repair rates or long-term mortality.

conclusionsWomen present at a later stage of the disease and with more complex MV pathology, resulting in lower repair and MIMVS rates and higher perioperative mortality. These disparities are largely attributable to disease morphology rather than sex per se. Earlier referral of women is essential to improve outcomes.

Indexed as

Heart Valve DiseasesHeart Valve Prosthesis ImplantationMitral ValveAgedFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesSex FactorsTreatment Outcomeminimal invasive surgerymitral valve diseasemitral valve surgerysex-differences

Identifiers

PMID41392323
PMCPMC12771641

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.