Evidence map›Paper›PMID 41392288›Full record

ArticleNPJ Parkinson's disease2025

Self-perceived life course sleep duration trajectories and risk and age at onset of Parkinson's disease.

Yi Fang, Rebecca Hardy, Kristine Yaffe, Simon J Little, Caroline M Tanner, Yue Leng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi FangDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Rebecca HardySchool of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, UK.
Kristine YaffeDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Simon J LittleMovement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Caroline M TannerMovement Disorders and Neuromodulation Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Yue LengDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA. Yue.Leng@ucsf.edu.

Funding

Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.R01AG083836 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yue Leng · 2024 to 2026
$2.1M
Development of novel polysomnography-based digital biomarkers to predict Alzheimer’s disease and Parkinson’s disease in real world settingsR21AG085495 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LENG, YUE · 2023 to 2023
$469k
NIA NIH HHS R01 AG083836NIA NIH HHS R01AG083836NIA NIH HHS R21 AG085495
6 · The paper itself

Abstract

Sleep disturbances are both prodromes and potential risk factors for Parkinson's disease (PD), yet associations between long-term sleep patterns and PD remain unclear. We analyzed data from two online cohorts-PPMI-Online (n = 15,905) and Fox Insight (n = 1929)-to examine associations between self-reported sleep duration trajectories across life stages and PD risk and age at onset (AAO). Latent class growth analysis identified distinct trajectories, linear and logistic regression examined their associations with PD risk and AAO, adjusting for demographics, lifestyle, and comorbidities. In PPMI-Online, sleep duration was generally stable in early adulthood with divergence in midlife. Compared to stable sleepers (7-8 h/day), individuals with midlife reductions (6-7 to ≤5-6 h/day: OR = 1.90; 7-8 to ≤6-7 h/day: OR = 1.64) and persistent short sleep (≤6 h/day: OR = 1.41) had higher PD risk, independent of comorbidities. Similar patterns were observed in probable prodromal PD. Persistent short sleep and sleep decline were also linked to earlier AAO (up to -4.23 years) across cohorts. These findings suggest that midlife sleep reduction may signal early PD, while chronic short sleep may represent a modifiable risk factor, highlighting the need for prospective studies to explore early detection and prevention potential.

Identifiers

PMID41392288
PMCPMC12738539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.