ArticleBMC public health2025
Associations of changes in frailty with multiple chronic diseases in middle aged and elderly adults.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the impact of baseline frailty status on chronic disease risks has been well-established, evidence on the associations between changes in frailty status and the incidence of new-onset chronic diseases remains limited.
methodsA retrospective study of prospectively collected data from the China Health and Retirement Longitudinal Study (CHARLS) including 7 021 adults aged 45 years or older. Frailty status was evaluated by the Rockwood frailty index and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty status at baseline (2011) and the second survey (2013). All chronic diseases were identified by self-reported physician diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs.
resultsCompared to stable robust participants, robust participants who progressed to pre-frail/frail status had significantly elevated risks of all chronic diseases studied (HRs: 1.38-2.73), except for cancer (HR: 1.32; 95% CI: 0.83-2.12). Pre-frail participants who progressed to frail status showed only significantly elevated risks of hypertension (HR: 1.34; 95% CI: 1.01-1.77) and memory disease (HR: 1.63; 95% CI: 1.11-2.39) compared to stable pre-frail participants. In contrast, pre-frail participants who recovered to robust status demonstrated decreased risks of CVD, heart disease, stroke, kidney disease, digestive disease, psychiatric disease, and memory disease than stable pre-frail participants (HRs: 0.39-0.66). Similarly, frail participants who recovered to robust/pre-frail status also showed decreased risks of CVD, stroke, diabetes, psychiatric disease, and memory disease compared to stable frail participants (HRs: 0.39-0.73).
conclusionsDifferent changes in frailty status are associated with different risks of new-onset chronic diseases. Progression of frailty status increases risks of almost all chronic diseases, while recovery of frailty status decreases risks of approximately half of all chronic diseases.
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