Evidence map›Paper›PMID 41392219›Full record

ReviewCellular and molecular neurobiology2025

Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer's Disease.

Yuzhen Shen, Xiaoran Wang, Xinyu Liu, Guoying Wang, Xueqin Hou, Xiaoming Zhou

Abstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Environmental Pollution, Biomarkers, and Dementia: An Evidence Review.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuzhen Shen *Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, Shandong Province, China.ORCID http://orcid.org/0009-0005-3468-0555
Xiaoran Wang *Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, Shandong Province, China.ORCID http://orcid.org/0009-0009-3755-7703
Xinyu LiuShandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, Shandong Province, China.ORCID http://orcid.org/0009-0003-4031-3132
Guoying WangThe Second People's Hospital of Dongying, No.6 Xinhua Road, Guangrao County, Dongying, 257335, Shandong Province, China. icuwangguoying@163.com.ORCID http://orcid.org/0009-0009-8360-6051
Xueqin HouSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University, No.6699 Qingdao Road, Huaiyin District, Jinan, 250100, China. houxueqin09@126.com.ORCID http://orcid.org/0000-0001-7075-3321
Xiaoming ZhouShandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, Shandong Province, China. zhouxiaoming@sdfmu.edu.cn.ORCID http://orcid.org/0000-0003-1398-5382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease closely associated with age. The main clinical manifestations include cognitive impairment, including visuospatial ability, memory, language, and behavioral disorders. These manifestations considerably impair the patients' ability to perform daily activities. Although the pathogenesis of AD remains unclear, many studies have confirmed the essential role of abnormal lipid metabolism and inflammatory response in AD occurrence and progression. In this review, based on the relationship between lipid metabolism disorders and neuroinflammation, the regulatory mechanism of lipid mediators, and the role of microglia, we systematically discuss how lipid metabolism affects the pathological process of AD by regulating the inflammatory response.

Indexed as

Alzheimer DiseaseInflammationLipid MetabolismNeuroinflammatory DiseasesAnimalsHumansMicrogliaAlzheimer's diseaseLipid metabolismMicrogliaNeuroinflammation

Identifiers

PMID41392219
PMCPMC12830530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.