Evidence map›Paper›PMID 41392186›Full record

ArticleScientific reports2025

Metabolite profiling and evaluation of antioxidant, antidiabetic, and antibacterial potential of Thymus linearis Benth. supported by molecular docking and PASS prediction.

Manisha Joshi, Geeta Tewari, Chitra Pande, Girish C Kharkwal, Lalit M Tewari, Vibha Joshi, Manisha Duseja, Aabha Gangwar, Vishwajeet Bachhar

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Phytochemical Characterization ofFood science & nutrition · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manisha JoshiDepartment of Chemistry, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India.
Geeta TewariDepartment of Chemistry, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India. geeta_k@rediffmail.com.
Chitra PandeDepartment of Chemistry, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India.
Girish C KharkwalDepartment of Chemistry, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India.
Lalit M TewariDepartment of Botany, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India.
Vibha JoshiDepartment of Chemistry, Dehradun Institute of Technology, Dehradun, 248009, Uttarakhand, India.
Manisha DusejaDepartment of Chemistry, Dehradun Institute of Technology, Dehradun, 248009, Uttarakhand, India.
Aabha GangwarDepartment of Chemistry, D. S. B. Campus, Kumaun University, Nainital, 263001, Uttarakhand, India.
Vishwajeet BachharDepartment of Chemistry, Dehradun Institute of Technology, Dehradun, 248009, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-based products have emerged as a high-rise need. Thymus linearis, a hilly herb, represents a promising resource of natural bioactive compounds. This work targets multiple impacts of essential oil of T. linearis, examining its chemical variability across different geographical regions, giving a GC-MS-based metabolite profile of T. linearis essential oil, along with tests done in vitro and in silico to see how well it works as an antioxidant (DPPH, ABTS, and metal chelating activity), antidiabetic (α-amylase assay), and antibacterial (disc-diffusion against E. coli and B. subtilis) agent. The essential oil was extracted via hydrodistillation from three locations: Ranikhet (RTL), Almora (ATL), and Lohaghat (LTL). Thymol (61.95% to 73.05%) was dominant in all three locations, with RTL being the maximum. The components like γ-terpinene, p-cymene, and β-(E)-caryophyllene were prominent in T. linearis in varying percentages. Oxygenated monoterpenes dominated the essential oils (RTL: 79.24%, ATL: 77.24%, LTL: 65.28%). RTL showed the best results in the DPPH test and exhibited antibacterial activity producing inhibition zones, even at a lower amount (200 µg/mL) against E. coli and B. subtilis strains that was similar to the standard. LTL demonstrated the best α-amylase assay. In silico molecular docking of thymol, γ-terpinene, and p-cymene was found to strongly attach to target proteins, backing up the lab results. PASS prediction and Lipinski's rule were also employed to support the present study.

Indexed as

Anti-Bacterial AgentsAntioxidantsHypoglycemic AgentsOils, VolatileThymus Plantalpha-AmylasesBacillus subtilisEscherichia coliGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsMolecular Docking SimulationPlant Extractsalpha-AmylasesAnti-Bacterial AgentsAntioxidantsHypoglycemic AgentsOils, VolatilePlant ExtractsAntibacterialAntidiabeticAntioxidantGC-MSMolecular dockingThymus linearis

Identifiers

PMID41392186
PMCPMC12820053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.