Evidence map›Paper›PMID 41392163›Full record

ArticleScientific reports2025

Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents.

Roberta Marongiu, Jingjing Wang, Santiago R Unda, Julie Barbera, Leandra Velazquez, Rosemary Li, Maria Jimenez-Gonzalez, William Tower, Neranjan de Silva, Rachel Retik and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberta MarongiuDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jingjing Wang *Department of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Santiago R Unda *Department of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Julie BarberaDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Leandra VelazquezDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Rosemary LiDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maria Jimenez-GonzalezDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
William TowerDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Neranjan de SilvaDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Rachel RetikDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Sarah A StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael G KaplittDepartment of Neurological Surgery, Weill Cornell Medicine, Cornell University, New York, NY, USA. mik2002@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vagal afferents originating in the upper gastrointestinal (GI) tract convey critical satiety signals but have remained challenging to target with precision. Here, we exploited a modified retrograde AAV2/rh10 vector delivered to the gastric wall to selectively transduce stomach-innervating nodose ganglion neurons and express the excitatory DREADD receptor hM3Dq. Chemogenetic activation of these afferents in mice acutely suppressed food intake by over 50% and induced robust c-Fos expression in neurons of the nucleus tractus solitarius and ventromedial (VMH) and arcuate nuclei of the hypothalamus, while chronic stimulation during high-fat feeding attenuated diet-induced weight gain by nearly 40%. This minimally invasive, organ-targeted gene-delivery strategy affords reversible control over visceral sensory pathways and holds promise as a foundation for novel obesity and metabolic-disorder therapies.

Indexed as

DependovirusFeeding BehaviorGastrointestinal TractNeurons, AfferentAnimalsDiet, High-FatEatingGenetic VectorsGene Transfer TechniquesMaleMiceMice, Inbred C57BLNodose GanglionSolitary NucleusAAV vectorsNeuronal modulationNodose ganglionNucleus tractus solitariusVagal afferent

Identifiers

PMID41392163
PMCPMC12804985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.