Evidence map›Paper›PMID 41392115›Full record

ArticleScientific reports2025

Glycopolymer binds pathogenic IgM autoantibodies and pulls them into the mononuclear phagocyte system for degradation.

Butrint Aliu, Delphine Demeestere, Lijuan Pang, Timothy Sharpe, Wolf Heusermann, Ruben Herrendorff, Beat Ernst, Pascal Hänggi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Butrint AliuMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland. butrint.aliu@hotmail.com.
Delphine DemeestereMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland.
Lijuan PangMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland.
Timothy SharpeBiophysics Facility, Biozentrum, University of Basel, 4056, Basel, Switzerland.
Wolf HeusermannImaging Core Facility, Biozentrum, University of Basel, 4056, Basel, Switzerland.
Ruben HerrendorffMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland.
Beat ErnstMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland. beat.ernst@unibas.ch.
Pascal HänggiMolecular Pharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland. pascalrhaenggi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-myelin associated glycoprotein (MAG) neuropathy patients exhibit high levels of monoclonal IgM autoantibodies against the carbohydrate epitope HNK-1 (human natural killer-1). This glycoepitope is abundantly presented on the adhesion molecule MAG as well as on other glycoconjugates of the peripheral nervous system. Binding of the autoantibodies results in demyelination of the peripheral nerves causing severe sensorimotor deficits in anti-MAG neuropathy patients, including paresthesias and sensory ataxia. We have previously reported the effective neutralization and removal of anti-HNK-1 IgM autoantibodies in an immunological mouse model with the glycopolymer PPSGG (poly-L-lysine

Indexed as

AutoantibodiesImmunoglobulin MPolylysineAnimalsHumansMacrophagesMiceAutoantibodiesImmunoglobulin MPolylysineAntigen specific glycopolymerAnti-MAG neuropathyMonoclonal gammopathy of neurological significanceMononuclear phagocyte systemScavenger receptors

Identifiers

PMID41392115
PMCPMC12706049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.