ArticleMolecular psychiatry2026
Attenuation of social preference and alteration of cortical neurons following adolescent cerebellar nuclei perturbation.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Connections between one of the main outputs of the cerebellar cortex, the lateral cerebellar nuclei (LCN), to reward-related circuits may explain social deficits resulting from cerebellar critical period perturbations. To examine the influence of LCN development on social behavior, local neural activity was manipulated in mice using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) from postnatal day 21-35. Adolescent social behavior was assessed using a three-chamber assay. Results revealed the LCN perturbation abolished male social preference. LCN manipulated mice were found to have less neural activation (cFos) in the ventral tegmental area, nucleus accumbens, and anterior cingulate cortex (ACC). Additionally, mice that received the excitatory DREADD perturbation showed increased dendritic complexity in the ACC. These results suggest a chronic perturbation in the LCN during juvenile and early adolescent development impacts social behavior and results in changes to cortical activity and structure observed in adolescence.
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