ArticleNature communications2025
A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Bioinspired 0D mitochondrial bioenergetic actuators rewire cartilage progenitor cell metabolism for osteoarthritis remission.Bioactive materials · 2026Article
- Preparation and Phase Transition Study of a Multi-Environmentally Sensitive Hydrogel.Gels (Basel, Switzerland) · 2026Article
- Nanoparticulate and Hydrogel Vehicles for Stimuli-Responsive and Sustained Controlled Release of Active Pharmaceutical Ingredients.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Injectable bioactive hydrogels as pharmacological drug delivery platforms for post-myocardial infarction cardiac repair: therapeutic cargo engineering, stimuli-responsive release mechanisms, and translational perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Mild Heat Stimulating and Microenvironment Reprogramming Hydrogel for Accelerating Diabetic Wound Healing.Gels (Basel, Switzerland) · 2026Article
- Astragaloside IV-Loaded Polydopamine/Zeolitic Imidazolate Framework-8 Nanoparticles Embedded in Conductive Decellularized Extracellular Matrix-Modified Hydrogels for Wound Healing.Pharmaceutics · 2026Article
- Freeze-Thaw-Induced Hybrid Porous PVA/PEG Hydrogels with Dynamic Load-Dissipation Capability for Cartilage Substitutes.Gels (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Organ functionalization is inherently complex and dynamic, involving multilayered tissue structures and continuous cellular remodeling. To address the clinical need for long-segment tracheal reconstruction, we propose a dynamic tissue engineering (DTE) strategy using a bio-adaptive physical hydrogel (BP-Gel) to emulate native tracheal development and enable dynamic regeneration of key tissue components. Here we show that chondrocytes cultured within BP-Gel form cartilage rings through an embryo-like chondrification process, during which the gel's percolation network adapts to cell migration and aggregation. The resulting cartilage exhibits a native-like multilayered morphology that enhances mechanical stability and resists degradation. Before transplantation, BP-Gel loaded with anti-inflammatory cytokines (IL-Gel) is introduced into inter-ring spaces to suppress inflammation and promote vascularization and epithelial maturation. In a rabbit tracheal defect model, this strategy reconstructs a functional trachea mimicking native structure and physiology, offering a promising, clinically relevant route to tracheal reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.