Evidence map›Paper›PMID 41392082›Full record

ArticleNature communications2025

Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8

Srijana Pokhrel, Gayathri Dileepan, Melissa R Leonard, Robert T Warren, Mariam Salem, Allison J Yacapraro, Qiaoke Gong, Devin M Jones, Jasmine A Tuazon, Kaitlin A Read and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Srijana PokhrelDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Gayathri DileepanDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Melissa R LeonardDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-1680-3620
Robert T WarrenDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Mariam SalemDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0009-0003-7039-4201
Allison J YacapraroDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Qiaoke GongDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Devin M JonesDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Jasmine A TuazonDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0001-9896-9714
Kaitlin A ReadDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Jacob S YountDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-6128-4575
Gang XinDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Adriana ForeroDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-2698-658X
Hazem E GhoneimDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-9816-4286
Patrick L CollinsDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0003-4550-4272
Emily A HemannDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA.
Kenneth J OestreichDepartment of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio, USA. Ken.Oestreich@osumc.edu.ORCID http://orcid.org/0000-0002-3004-072X

Funding

Identifying novel regulatory pathways underlying T helper 1 cell immune responsesR01AI134972 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI OESTREICH, KENNETH JOSEPH · 2018 to 2022
$1.9M
RIG-I-like receptor regulation of pulmonary inflammation and homeostasisR35GM150503 · NIGMS · OHIO STATE UNIVERSITY · PI Emily Ann Hemann · 2023 to 2026
$1.6M
Interdisciplinary Program in Microbe-Host BiologyT32AI165391 · NIAID · OHIO STATE UNIVERSITY · PI RAJENDAR K DEORA, Daniel J Wozniak · 2022 to 2026
$1.5M
The Ikaros zinc finger transcription factor Eos as a candidate regulator of TH2 differentiation and effector functionF30AI172189 · NIAID · OHIO STATE UNIVERSITY · PI TUAZON, JASMINE ASHLEY · 2024 to 2024
$37k
NIAID NIH HHS F30 AI172189NIAID NIH HHS R01 AI134972NIAID NIH HHS T32 AI165391NIGMS NIH HHS R35 GM150503U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI134972
6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesIkaros Transcription FactorImmunologic MemoryMemory T CellsAnimalsGranzymesInfluenza A virusInterferon-gammaInterleukin-2 Receptor beta SubunitLungMiceMice, Inbred C57BLMice, KnockoutOrthomyxoviridae InfectionsT-Box Domain ProteinsEomes protein, mouseGranzymesGzmb protein, mouseIkaros Transcription FactorInterferon-gammaInterleukin-2 Receptor beta SubunitT-Box Domain Proteins

Identifiers

PMID41392082
PMCPMC12827986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.