Evidence map›Paper›PMID 41392066›Full record

Observational studyInternal and emergency medicine2026

Impact of age on functional recovery following hospital-based rehabilitation in older adults.

Alessandra Petrelli, Tiziano Nestola, Cesare Mainetti, Sarah Catarame, Francesca Giani, Giovanna Esposti, Gessica Nicodemi, Calogero Malfitano, Paolo Fiorina, Francesco Dentali and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recovery capital: a concept analysis.Frontiers in public health · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alessandra PetrelliDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-27, University of Milan, Via Festa del Perdono, 7, 20122, Milano, Italy. alessandra.petrelli@unimi.it.ORCID 0000-0002-5639-9415
Tiziano NestolaPio Albergo Trivulzio, Milan, Italy.
Cesare MainettiPio Albergo Trivulzio, Milan, Italy.
Sarah CataramePio Albergo Trivulzio, Milan, Italy.
Francesca GianiPio Albergo Trivulzio, Milan, Italy.
Giovanna EspostiPio Albergo Trivulzio, Milan, Italy.
Gessica NicodemiSchool of Geriatrics, University of Milan, Milan, Italy.
Calogero MalfitanoPio Albergo Trivulzio, Milan, Italy.
Paolo FiorinaInternational Center for T1D, Pediatric Clinical Research Center Romeo Ed Enrica Invernizzi, DIBIC, Università Degli Studi Di Milano, Milan, Italy.
Francesco DentaliUniversità Degli Studi Dell'Insubria, Varese, Italy.
Stefania IaconoPio Albergo Trivulzio, Milan, Italy.
Nadia AntoniottiPio Albergo Trivulzio, Milan, Italy.
Sonia BaruffiPio Albergo Trivulzio, Milan, Italy.
Antonella FerrariPio Albergo Trivulzio, Milan, Italy.
Marco FroldiDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-27, University of Milan, Via Festa del Perdono, 7, 20122, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With a rapidly aging population, accurately predicting rehabilitation outcomes in older adults is increasingly important. As the impact of age on recovery trajectories in geriatric rehabilitation remains unclear, we conducted a retrospective observational study to evaluate the effect of older age on improvements in rehabilitation functional outcomes. We included 158 patients (median age: 84 years; IQR: 77.0-88.0) admitted in 2024 to a geriatric rehabilitation unit. Functional status was assessed at admission and discharge using the Modified Barthel Index (autonomy), Hendrich II Fall Risk Model (fall risk), and Tinetti Scale (balance and gait). Patients were stratified into age tertiles and compared using the Kruskal-Wallis and Mann-Whitney U tests. Multivariable linear regression models evaluated the independent associations of age, sex, and frailty index with functional outcomes. Comparisons of changes in functional outcomes between the youngest (T1) and oldest (T3) age tertiles were performed using the Mann-Whitney U test. Older age was associated with worse baseline functional status, reflected by lower Barthel and Tinetti scores and higher Hendrich II scores. However, in multivariable models, frailty index-but not chronological age-was the strongest independent predictor of all functional outcomes, including Barthel (β =  -89.9, p < 0.001), Tinetti (β =  -39.9, p < 0.001), and Hendrich II (β = 6.8, p < 0.001). Both younger and older patients achieved significant functional gains, particularly in mobility, whereas improvements in autonomy and fall risk were more limited among the oldest individuals. In conclusion, chronological age was associated with poorer baseline performance but did not impair motor recovery. Frailty, rather than age itself, emerged as the key determinant of rehabilitation outcomes. These findings underscore the importance of integrating standardized frailty assessments to guide rehabilitation strategies and promote equitable access to multidisciplinary rehabilitation for older adults.

Indexed as

Recovery of FunctionAgedAged, 80 and overAge FactorsFemaleFunctional StatusGeriatric AssessmentHumansMaleRetrospective StudiesAgedFrailtyGeriatric assessmentInpatientsRecovery of functionRehabilitation

Identifiers

PMID41392066
PMCPMC13061775

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.