Evidence map›Paper›PMID 41392057›Full record

ArticleArchives of virology2025

Metabolic profiling of baculovirus infection in Helicoverpa armigera fat body shows that Mamestra brassicae multiple nucleopolyhedrovirus promotes self-replication by increasing the synthesis of phosphatidylcholine.

Hanwen Cao, Zhenpu Liang, Guozhi Zhang, Xinping Yang, Xiaoxia Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanwen Cao *College of Life Sciences, Henan Agricultural University, 450002, Zhengzhou, China.ORCID http://orcid.org/0009-0005-5340-4310
Zhenpu LiangCollege of Life Sciences, Henan Agricultural University, 450002, Zhengzhou, China. lzpbio@126.com.
Guozhi ZhangCollege of Life Sciences, Henan Agricultural University, 450002, Zhengzhou, China.
Xinping YangInstitute of Microbiology, Xinjiang Academy of Agricultural Sciences, 830000, Urumqi, China.
Xiaoxia Zhang *College of Life Sciences, Henan Agricultural University, 450002, Zhengzhou, China. lzpzxx@126.com.

Funding

Special Project on Key Research and Development Tasks of Xinjiang Uygur Autonomous Region No. 2022B02019Support Program for Innovative Development of Nanjiang Key Industries No. 2022DB026
6 · The paper itself

Abstract

Mamestra brassicae multiple nucleopolyhedrovirus (MbMNPV) has been widely used as a biocontrol agent against Helicoverpa armigera in China. To understand the relationship between the metabolic response in H. armigera and MbMNPV infection, we analyzed the overall metabolic changes occurring in H. armigera fat bodies during MbMNPV infection. The metabolomic data identified 135 differentially expressed metabolites (DEMs) in the MbMNPV-infected group. Based on the metabolomic data, the changes in phosphatidylcholine levels during the entire infection period and its effect on virus replication were determined. The results showed that virus infection led to a significant upregulation of phosphatidylcholine in H. armigera. Phosphatidylcholine supplementation shortened the median lethal time (LT

Indexed as

Fat BodyMothsNucleopolyhedrovirusesPhosphatidylcholinesVirus ReplicationAnimalsHelicoverpa armigeraLarvaMetabolomicsPhosphatidylcholinesHelicoverpa armigeraLPCAT5MbMNPVMetabolomicsPhosphatidylcholine

Identifiers

PMID41392057

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.