ArticleNPJ science of food2025
Development of an intestinal allergy model to evaluate the initial introduction of infant rice cereal.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Toxicological evaluation of a synthetic QS-21 adjuvant in a tuberculosis vaccine candidate-Demonstrating safety and immunological equivalence to natural reference.Human vaccines & immunotherapeutics · 2026Article
- Quercetin Attenuates Oxidative Stress and Immune Inflammation via Modulating Heme and ROS Pathways in Rats Fed Protein-Oxidized Soybean Meal.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Infant rice cereal (IRC), presents an increasing risk of allergic reactions upon initial exposure, effective assessment models remain underdeveloped. This study established an intestinal allergy model in female Wistar rats using lipopolysaccharide (LPS) as an adjuvant to simulate first-time IRC exposure. Clinical symptoms, physiological indicators, and immunological analyses results demonstrated that LPS triggered intestinal allergic responses and elevated serum levels of immunoglobulins (IgE, IgG, IgA, IgD, IgM), mast cell markers (mMCP-1 and MCT), and plasma histamine (HIS). Intestinal tissue analysis revealed significant increases in IgE, secretory IgA, HIS, and complement (C3, C4) in the jejunum and ileum, confirming these regions as key mucosal immune activation sites. Furthermore, LPS-induced responses were localized to the intestines and did not alter spleen or thymus cytokines. The proposed model effectively simulates IgE-mediated intestinal allergy to IRC, thereby offers a reliable platform for evaluating IRC allergenic variations and supporting safer infant complementary food development.
Identifiers
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Registered trials
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