Evidence map›Paper›PMID 41391486›Full record

ArticleJournal of microbiology and biotechnology2025

Francesco Di Pierro, Gayathri Veeraraghavan, Kuppusamy Kalaiselvan, Bahrudeen Ashif, Logeshwari Jeyakumar, Gopikrishnan Gopalakrishnan, Massimiliano Cazzaniga, Alexander Bertuccioli, Maria Laura Tanda, Nicola Zerbinati and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06370208 (Study to Investigate the Prophylactic Effect of Streptococcus Salivarius eK12 Against Recurrent Group A Streptococcal Pharyngotonsillitis in Children), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06370208 nacompletednot on this map

Study to Investigate the Prophylactic Effect of Streptococcus Salivarius eK12 Against Recurrent Group A Streptococcal Pharyngotonsillitis in Children: A Randomized, Double-Blind, Parallel-Group Controlled Trial

TypeinterventionalSponsorLiaquat University of Medical & Health SciencesRan2025 to 2026Enrolled82ConditionsStreptococcus Pyogenes PharyngotonsillitisArmsProbiotic Bactoblis® EVOL (Streptococcus salivarius eK12), Oral vit D3
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesco Di PierroVelleja Research, Scientific Department, Milano, Italy.
Gayathri VeeraraghavanCentre For Toxicology and Developmental Research (CEFTE), Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, India.
Kuppusamy KalaiselvanCentre For Toxicology and Developmental Research (CEFTE), Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, India.
Bahrudeen AshifCentre For Toxicology and Developmental Research (CEFTE), Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, India.
Logeshwari JeyakumarDiligence Bio Labs, Pondicherry, India.
Gopikrishnan GopalakrishnanDiligence Bio Labs, Pondicherry, India.
Massimiliano CazzanigaVelleja Research, Scientific Department, Milano, Italy.
Alexander BertuccioliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Maria Laura TandaEndocrine Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Nicola ZerbinatiDepartment of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
Ikram UjjanDepartment of Pathology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan.
Ali Akbar BugtiCentre for Inflammation Research, University of Edinburgh, UK.
Aasiya BanoResearch & Innovation Unit, National Emergency Operation Centre (NEOC), Islamabad, Pakistan.
Yasmeen GullDHQ Hospital, Turbat, Pakistan.
Nasrin MumtazJam Ghulam Civil Hospital, Hub, Pakistan.
Amjad KhanNuffield Division of Clinical Laboratory Sciences (NDCLS), Radcliffe Department of Medicine, University of Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group A

Indexed as

ProbioticsStreptococcus salivariusAdministration, OralAnimalsFemaleMutagenicity TestsRatsRats, Sprague-DawleyRats, WistarSalmonella typhimuriumStreptococcal Infectionsacute oral toxicityames testfood safetygenetic modificationprobiotic safetyStreptococcus salivarius eK12sub-chronic toxicity

Identifiers

PMID41391486
PMCPMC12706148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.