Evidence map›Paper›PMID 41391234›Full record

ArticleEnvironment international2026

Serum per- and polyfluoroalkyl substances in relation to circulating thyroxine levels and thyroid cancer risk: results from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort.

Eun Mi Jung, Jongeun Rhee, Alexander P Keil, Cari M Kitahara, Steven C Moore, Jani Koponen, Panu Rantakokko, Mark P Purdue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eun Mi JungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Jongeun RheeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Alexander P KeilDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Jani KoponenLifestyles and Environments Unit, Finnish Institute of Health and Welfare, Kuopio, Finland.
Panu RantakokkoLifestyles and Environments Unit, Finnish Institute of Health and Welfare, Kuopio, Finland.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address: purduem@mail.nih.gov.

Funding

Cancer Risk and Environmental ExposuresZIACP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$41.3M
Intramural NIH HHS ZIA CP010125
6 · The paper itself

Abstract

This study investigated whether serum levels of per- and polyfluoroalkyl substances (PFAS) are associated with circulating thyroxine levels and thyroid cancer within a cohort study with exposure levels comparable to that of the U.S. general population. We conducted a nested case-control study of thyroid cancer (189 cases, 378 individually matched controls) investigating serum concentrations of five PFAS within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) Cohort. Additionally, a meta-analysis of serum perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in relation to thyroxine levels was performed across seven PLCO metabolomic investigations totaling 3,389 participants. Odds ratios (ORs) and 95% confidence intervals (CIs) relating thyroid cancer associations with serum PFAS concentrations were computed using multivariable conditional logistic regression. We analyzed thyroxine associations with PFOA and PFOS using study-specific multivariable linear regression models followed by random effects meta-analysis. We observed inverse associations with thyroid cancer for PFOA (fourth vs. first quartile: OR = 0.47, 95 % CI = 0.27, 0.80; P

Indexed as

Environmental ExposureEnvironmental PollutantsFluorocarbonsThyroid NeoplasmsThyroxineAgedAlkanesulfonic AcidsCaprylatesCase-Control StudiesCohort StudiesFemaleHumansMaleMiddle AgedAlkanesulfonic AcidsCaprylatesEnvironmental PollutantsFluorocarbonsperfluorooctane sulfonic acidperfluorooctanoic acidThyroxineCancerPer- and polyfluoroalkyl substancesSerumThyroid cancerThyroxine

Identifiers

PMID41391234
PMCPMC12884415

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.