ArticleAnalytical chemistry2025
Utilizing Engineered Monobodies for the Electrochemical Quantification of Lysozyme.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Review and Analysis of Electrochemical Instrumentation Design for Continuous Multi-Analyte Microfluidic Sensor Arrays.Sensors (Basel, Switzerland) · 2026Review
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Authors and funding
4 authors.
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Abstract
Monobody binding proteins are derived from the Fn3 domain of human fibronectin. These robust proteins can be engineered to bind to a wide range of small molecule-, nucleotide-, or large biomolecule-based analytes with high specificity and stability, thus making them ideal for biosensing applications. Here, we demonstrate an electrochemical biosensor utilizing an engineered monobody as a biorecognition element for the detection of lysozyme as a model biomarker. An engineered monobody binding protein was immobilized onto glassy carbon electrodes through a process of electrochemical grafting to create the sensing interface, while a water-soluble ferrocene derivative was used as an electrochemical indicator. Square wave voltammetry of resulting monobody-modified electrodes revealed a significant decrease in peak current density upon incubation with 24 μM lysozyme (250 ± 20 μA cm
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