Evidence map›Paper›PMID 41391036›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Circular RNA PTPN4 Contributes to Blood-Brain Barrier Disruption during Early Epileptogenesis.

Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiurong YangDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Yang HuDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Feiyu WangDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Xintao PengDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Honggang QiDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Yuanyuan YaoDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Canyu ZhangDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Lijie ZhouDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Xuemei LiangDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Kang XuDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Cong ZhangDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.
Aifeng ZhangDepartment of Pathology, Medical School of Southeast University, Nanjing, 210009, China.
Chen ChenFunctional Experimental Center, Medical School of Southeast University, Nanjing, 210009, China.
Yu ZengNational Residents Clinical Skills Training Center, Medical School of Southeast University, Nanjing, 210009, China.
Chenchen ZhangTransmission Electron Microscopy Center, Medical School of Southeast University, Nanjing, 210009, China.
Guangming GanTransmission Electron Microscopy Center, Medical School of Southeast University, Nanjing, 210009, China.
Xinjian ZhuDepartment of Pharmacology, Medical School of Southeast University, Nanjing, 210009, China.ORCID https://orcid.org/0000-0001-8386-4952

Funding

Fundamental Research Funds for the Central Universities 2242017K3DN33Fundamental Research Funds for the Central Universities 2242017K40095National Natural Science Foundation of China 81673413National Natural Science Foundation of China 81872846National Natural Science Foundation of China 82471486Natural Science Foundation of Jiangsu Province BK20141335
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are crucial regulators of gene expression, exhibiting dynamic expression patterns during both normal brain development and diverse pathological states. This study reports the elevated expression of CircPTPN4 in the brain tissue and plasma during early epileptogenesis in a murine temporal lobe epilepsy model. Overexpression of CircPTPN4 disrupts the tight junctions of brain microvascular endothelial cells (BMECs), compromising blood-brain barrier (BBB) integrity. Mechanistically, CircPTPN4 functions as a competitive endogenous RNA by sequestering miR-145a-5p, thereby upregulating endothelin-converting enzyme-1 (ECE-1). Subsequent ECE-1-mediated endothelin-1 (ET-1) production activates the p38/MAPK pathway, downregulating tight junction protein expression. Knockdown of CircPTPN4 attenuated tight junction disruption and BBB impairment during acute epileptogenesis while reducing spontaneous seizure frequency in chronic epilepsy. These findings establish the CircPTPN4/miR-145a-5p/ECE-1 axis as both a diagnostic biomarker and therapeutic target for BBB preservation in early-stage epilepsy.

Indexed as

Blood-Brain BarrierEpilepsy, Temporal LobeRNA, CircularAnimalsDisease Models, AnimalEndothelial CellsEndothelin-Converting EnzymesHumansMaleMiceMicroRNAsEndothelin-Converting EnzymesMicroRNAsMIRN145a microRNA, mouseRNA, Circularblood‐brain barriercircPTPN4endothelin converting enzyme‐1epilepsymiR‐145

Identifiers

PMID41391036
PMCPMC12948252

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.