Evidence map›Paper›PMID 41390920›Full record

ArticleGenomics, proteomics & bioinformatics2025

A Human-specific Protein Regulated by Alternative Polyadenylation Shapes Uniqueness of Human Brain Development.

Ting Li, Fan Mo, Jianhuan Qi, Chunqiong Li, Xiangshang Li, Jie Zhang, Yingfei Lu, Chao Yao, Li Zhang, Baoyang Hu and 2 more

Abstract read
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In one paragraph

Article in Genomics, proteomics & bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ting LiState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0009-0003-1635-7864
Fan MoUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-0881-0062
Jianhuan QiUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-8056-1312
Chunqiong LiState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0009-0007-3578-2208
Xiangshang LiState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0000-0002-4786-3247
Jie ZhangState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0000-0002-6269-3637
Yingfei LuSavaid Medical School, University of Chinese Academy of Sciences, Beijing 101408, China.ORCID 0009-0002-7069-9104
Chao YaoState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0009-0002-9364-0789
Li ZhangChinese Institute for Brain Research, Beijing 102206, China.ORCID 0000-0002-0698-0754
Baoyang HuUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0003-3993-4014
Chuan-Yun LiState Key Laboratory of Protein and Plant Gene Research, Laboratory of Bioinformatics and Genomic Medicine, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100080, China.ORCID 0000-0002-8008-8430
Ni A AnInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-9179-4106

Funding

Chinese Academy of Sciences E4651K0102Ministry of Science and Technology of China 2018YFA0801405Ministry of Science and Technology of China 2019YFA0801801National Natural Science Foundation of China 32300510University for insightful suggestions
6 · The paper itself

Abstract

Although new genes and regulatory events have been linked to the uniqueness of human brain development, it is unknown whether alternative polyadenylation (APA) also contributes to shaping this key feature that differentiates humans from other species. Here, we present an atlas of APAs of the human brain and identified 161 development-related, open-reading-frame-disrupting APAs associated with the dynamic translation of protein products. Among the genes affected by these events, we identified ZNF271P, which encodes a human-specific protein when using the distal polyadenylation site, a site that preferentially occurs during early brain development. The cortical organoids derived from ZNF271P-knockout human embryonic stem cells seemed to exhibit accelerated development and maturation, resulting in a significant decrease in organoid size, implicating that ZNF271P is involved in features unique to human brain development. We thus highlight APAs as new regulators in shaping the unique aspects of human brain development.

Indexed as

BrainPolyadenylationGene Expression Regulation, DevelopmentalHumansOrganoidsAlternative polyadenylationHuman brain developmentHuman-specific proteinORF-disrupting APAZNF271P

Identifiers

PMID41390920
PMCPMC13197124

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