Platinum Accumulation and Antioxidant Dysregulation Drive Behavioral Impairments, Apoptosis and Neurodegeneration in Oxaliplatin Exposed Drosophila Melanogaster.

Lopamudra Mishra, Monalisa Mishra

Abstract read

In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lopamudra MishraNeural Developmental Biology Lab, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India.

Monalisa MishraNeural Developmental Biology Lab, Department of Life Science, National Institute of Technology, Rourkela, 769008, Odisha, India. mishramo@nitrkl.ac.in.

Funding

University Grants Commission 211610083530

6 · The paper itself

Abstract

Chemotherapy is a conventional and extensively used method for cancer treatment. There is a growing burden on patients and society due to the adverse effects of chemotherapeutics, even though survival rates are improving. Oxaliplatin is a widely used platinum-based drug for colorectal cancer treatment. But the prolonged usage of these drugs is linked to neurotoxicity, which is considered as one of the dose-limiting adverse effects. Drosophila melanogaster is an ideal model organism due to its short generation time, low maintenance costs, and well-characterized genome and is extensively employed to investigate neurological disorders, DNA damage, oxidative stress, and apoptosis-like mechanisms are analogous to mammalian systems. We aimed to examine the toxic effects of Oxaliplatin using the lowest dose (20 µg/mL) and highest dose (200 µg/mL) below LC

Indexed as

Antineoplastic AgentsAntioxidantsApoptosisBehavior, AnimalDrosophila melanogasterOrganoplatinum CompoundsOxaliplatinPlatinumAnimalsDNA DamageOxidative StressReactive Oxygen SpeciesAntineoplastic AgentsAntioxidantsOrganoplatinum CompoundsOxaliplatinPlatinumReactive Oxygen SpeciesApoptosisDrosophila melanogasterOxaliplatinOxidative stressPlatinum-DNA adduct

Identifiers

PMID41390911

DOI10.3791/54809

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.