ArticleScientific reports2025
Characterization of broad host range bacteriophages vKpIN31 and vKpIN32 against hospital-acquired Klebsiella pneumoniae in Dakar, Senegal.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Advances in Molecular Microbiology-From Recent Advances to the Future.Current issues in molecular biology · 2025Article
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14 authors.
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Abstract
Klebsiella pneumoniae, a common gut colonizer, has become a major opportunistic pathogen, especially with the rise of multidrug-resistant (MDR) strains. This study aimed to characterize two lytic bacteriophages against MDR K. pneumoniae strains isolated from hospital associated infections in Senegal. Among 28 MDR K. pneumoniae strains tested, phage vKpIN31 effectively lyse 15 strains encompassing 12 distinct K locus types. While phage vKpIN32 lysed 12 strains with 9 different K locus types, demonstrating broad host range activity. The isolated phages exhibited thermal and pH stability. One-step growth analysis revealed a latent period of 25 and 20 min and burst sizes of 281 and 246 PFU/cell for vKpIN31 and vKpIN32 respectively. The in vitro lytic activity of phages vKpIN31 and vKpIN32 at different multiplicity of infection (1, 10
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