Evidence map›Paper›PMID 41390869›Full record

ArticleScientific reports2025

Efferent control of hair cells mechanically coupled by artificial membranes.

Martín A Toderi, Gabriela Muñoz-Hernandez, Justin Faber, Dolores Bozovic

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martín A ToderiDepartment of Physics & Astronomy, University of California, Los Angeles, Los Angeles, CA, 90095, USA. mtoderi@physics.ucla.edu.
Gabriela Muñoz-HernandezDepartment of Physics & Astronomy, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Justin FaberDepartment of Physics & Astronomy, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Dolores BozovicDepartment of Physics & Astronomy, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Funding

Air Force Office of Scientific Research FA9550-23-1-0713
6 · The paper itself

Abstract

The efferent system has been proposed to play a vital function in auditory and vestibular systems, by protecting the sensory hair cells from injury and preserving signal detection sensitivity. We report that the activation of efferents has strong modulatory effects on systems of coupled hair cell bundles. In this study, we use direct electrical stimulation of efferent neurons to probe its effects on the hair cells' internal dynamics, by means of optically tracking the hair bundle motility. In vivo, hair bundles of auditory and vestibular epithelia are connected via overlying membranes; to address this physiological characteristic, we investigate the impact of efferent activity on the collective response of coupled hair bundles. We use a preparation from the American bullfrog sacculus which preserves the active motility of hair bundles, and achieve inter-cell coupling by connecting the cells to artificial mica structures. We found that efferent stimulation impacts hair-bundle dynamics, affecting the amplitude, frequency, and temporal profile of spontaneous oscillations, and altering the dynamical state of the system. Furthermore, efferent activation decreased synchronization among coupled hair bundles, suggesting a mechanism by which neural modulation may reduce the overall sensitivity of the system.

Indexed as

Hair Cells, AuditoryHair Cells, VestibularNeurons, EfferentAnimalsElectric StimulationRana catesbeianaSaccule and UtricleCoupled hair bundlesEfferent feedbackHair cellsSensory systems

Identifiers

PMID41390869
PMCPMC12800259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.