Evidence map›Paper›PMID 41390813›Full record

ArticleHead & face medicine2025

The role of otorhinolaryngologists in the treatment of hereditary hemorrhagic telangiectasia.

René Lehner, Robin Lochbaum, Thomas K Hoffmann, Jens Greve

Abstract read
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Article in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

René LehnerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ulm, Frauensteige 12, Ulm, 89075, Germany. rene.lehner@uniklinik-ulm.de.
Robin LochbaumDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ulm, Frauensteige 12, Ulm, 89075, Germany.
Thomas K HoffmannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ulm, Frauensteige 12, Ulm, 89075, Germany.
Jens GreveDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ulm, Frauensteige 12, Ulm, 89075, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease which affects the entire vascular system. Symptoms vary from mild complaints to severe complications and are highly individual. Therapy is strictly symptomatic and creates an interdisciplinary challenge with relevant involvement of otorhinolaryngologists (ORL). The aim of this study is to evaluate this involvement.

methodsA retrospective analysis between 01/2006 and 12/2023 at Ulm University Medical Center was conducted. Two collectives were defined, the first one representing all patients who have been treated in any department for HHT, in order to draw a comparison between the departments. The second focused specifically on patients treated in the ORL department, providing a detailed analysis that includes emergency visits, hospital admissions, interventions and blood transfusions.

resultsIn the 1st collective 252 patients were identified generating 1092 cases. 43.3% of the patients were primarily treated at the ORL department, 24.0% at the dermatology department and 13.1% in internal medicine. The ORL patients generated significantly more cases as other specialties (p = 0.0001). The 2nd collective consisted of 105 patients. Men were more likely to be hospitalized (p = 0.0001) and to receive blood transfusions (p = 0.0045). There were no other gender specific differences. Symptoms and the need for medical help were independent of the season. A vast variety of visits, admissions and interventions could be shown.

conclusionORL specialists play a critical role in the management of HHT patients. The study shows the year-round necessity for specialized care. Sex-related differences should be taken into account. Besides multidisciplinary therapy strategies further prospective research is essential.

Indexed as

OtolaryngologistsOtolaryngologyPhysician's RoleTelangiectasia, Hereditary HemorrhagicAdultAgedBlood TransfusionFemaleGermanyHumansMaleMiddle AgedRetrospective StudiesArteriovenous malformationsEpistaxisHHTORL

Identifiers

PMID41390813
PMCPMC12702161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.