Evidence map›Paper›PMID 41390778›Full record

ArticleScientific reports2025

Multi-task learning identifies shared genetic risk for late-onset epilepsy and alzheimer's disease.

Mingzhou Fu, Thai Tran, Bogdan Pasaniuc, Keith Vossel, Timothy S Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mingzhou FuMary S. Easton Center for Alzheimer's Research and Care, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Thai TranMedical Informatics Home Area, Department of Bioinformatics, University of California, Los Angeles, CA, 90095, USA.
Bogdan PasaniucGenomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Keith VosselMary S. Easton Center for Alzheimer's Research and Care, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.
Timothy S ChangMary S. Easton Center for Alzheimer's Research and Care, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. timothychang@mednet.ucla.edu.

Funding

Astrocyte and neuron brain-region and compartment-specific proteome dynamics in aging and Alzheimer’s diseaseR01AG075955 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT, VOSSEL, KEITH ALAN · 2021 to 2025
$5.2M
In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles CountyUH3AG083254 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Keith Alan Vossel · 2025 to 2026
$2.3M
Identifying Undiagnosed Alzheimer’s Disease in Understudied PopulationsR01AG085518 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Timothy S Chang · 2024 to 2026
$2.3M
Preventing Seizures and Associated Memory Loss in Alzheimer's Disease by Blocking Tau Interactions with SH3-containing Proteins.R01AG058820 · NIA · UNIVERSITY OF MINNESOTA · PI VOSSEL, KEITH ALAN · 2019 to 2023
$1.9M
Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles CountyUH2AG083254 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VOSSEL, KEITH ALAN · 2023 to 2024
$1.1M
NIA NIH HHS R01 AG058820NIA NIH HHS R01 AG075955NIA NIH HHS R01 AG085518NIA NIH HHS UH2 AG083254NIA NIH HHS UH3 AG083254NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

Aging populations face increasing incidence of neurological disorders, including Alzheimer's disease (AD) and late-onset epilepsy (LOE), which demonstrate a bidirectional relationship where AD is a risk factor for LOE and LOE is a risk factor for AD. While the APOE gene is a known shared risk factor, comprehensive genetic studies for LOE remain limited. This study employed a multi-task learning framework using Elastic Net modeling to systematically identify shared genetic risk factors between AD and LOE. We analyzed electronic health records from UCLA Health System (N = 416,212; genetic subset N = 16,500) and validated findings in the All of Us dataset (N = 52,493). Longitudinal analyses confirmed strong bidirectional associations between AD and LOE. The multi-task learning approach identified eight shared-risk single nucleotide polymorphisms mapping to key genes including the APOE-TOMM40-APOC1 cluster, BIN1, CLU, PVRL2, and TRAPPC6A. These shared-risk genes were enriched in pathways related to lipid metabolism, amyloid catabolic processes, and tau protein binding. A shared genetic risk score effectively stratified patients into distinct AD-LOE risk groups. This study represents an initial systematic identification of potential shared genetic factors between AD and LOE using multi-task learning. While our findings suggest possible shared genetic contributions, particularly in the APOE region, and highlight tau-mediated mechanisms as potential therapeutic targets, further validation is needed to establish the extent of genetic overlap between these conditions.

Indexed as

Alzheimer DiseaseEpilepsyGenetic Predisposition to DiseaseAgedAged, 80 and overAge of OnsetApolipoproteins EClusterinFemaleHumansMalePolymorphism, Single NucleotideRisk FactorsApolipoproteins ECLU protein, humanClusterinAlzheimer’s diseaseElectronic health recordLate-onset epilepsyMulti-task learningShared genetic risks

Identifiers

PMID41390778
PMCPMC12820071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.