ArticleNPJ vaccines2025
Evaluation of cross-functional antibody responses elicited by a four-component GMMA Shigella vaccine.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Protective and pathogenic antibody responses from a primate Shigella outbreak inform vaccine design.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shigella is a major cause of morbidity and mortality in children in low- and middle-income countries. The O-antigen (OAg) component of the lipopolysaccharide is considered a protective antigen, however, their diversity challenges vaccine development, since more than 50 OAg serotypes have been identified. No licensed vaccine against shigellosis is available. A 4-component GMMA-based vaccine, altSonflex1-2-3, delivering S. sonnei and S. flexneri 1b, 2a and 3a OAg has been developed. Coverage is expected against non-vaccine serotypes, due to cross-reactivity, mediated by structural similarities among S. flexneri OAg. The vaccine is currently being tested in phase I and II clinical trials. In this work, sera from mice, rats, and rabbits injected with altSonflex1-2-3 were analyzed for their ability to bind to and kill S. flexneri serotypes not included in the vaccine. Results obtained were compared to corresponding results from vaccinated European adults. While no cross-reactive antibodies were measured in mouse sera, the antibodies elicited by altSonflex1-2-3 in rats, rabbits and humans were able to bind and kill the tested S. flexneri X, Y, 6, 4a and 5b strains. A study in African children and infants will confirm how data from animal models may predict the immune response in different age groups.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.