ArticleNPJ Parkinson's disease2025
Creatine-weighted imaging in patients with Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Liposomal and Polymeric Drug Delivery of Creatine: Exploring a Multifaceted Molecule for Neurodegenerative Diseases and Beyond.International journal of nanomedicine · 2026Review
Corrections and comments
- Update of
Authors and funding
8 authors.
Funding
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder featured impaired bioenergetics and mitochondrial dysfunction. Creatine (Cr) supplementation has been suggested as a pathophysiology-targeted treatment strategy; however, clinical outcomes remain inconsistent despite encouraging preclinical findings. The lack of methods to measure Cr distribution in the human brain may hinder the investigation. This study utilized a novel neuroimaging technique, guanidino chemical exchange saturation transfer (GuanCEST) MRI, to assess regional Cr levels in patients with PD (PwPD) and healthy controls (HCs). Twenty-five patients with PD and 24 age- and sex-matched HCs were enrolled. GuanCEST values in the caudate nucleus were significantly lower in PwPD (1.67 ± 0.26%) than HCs (1.82 ± 0.16%), p = 0.023. Moreover, GuanCEST signal reductions correlated with increasing PD severity, particularly in thalamic subregions. Kendall's correlation revealed a significant negative correlation between GuanCEST values in the internal medullary lamina and MDS-UPDRS-III scores (r = -0.44, p = 0.03). Regional ANCOVA further indicated that GuanCEST values in this region decreased by approximately 0.01% per unit increase in MDS-UPDRS-III (p = 0.007), adjusted for age and sex. These findings highlight GuanCEST MRI's potential as a noninvasive biomarker of Cr metabolism in PD, offering insights into disease mechanisms, therapeutic optimization, and clinical trial designs.
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Registered trials
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