Evidence map›Paper›PMID 41390679›Full record

ArticleNature communications2025

Hierarchically structuralized hydrogels with ligament-like mechanical performance.

Diwei Shi, Donghwan Ji, Jinhye Bae

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. AI-powered the toughest biohydrogels.Bioactive materials · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diwei Shi *Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Donghwan Ji *Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2266-1654
Jinhye BaeMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA. jbae@cau.ac.kr.ORCID http://orcid.org/0000-0002-2536-069X

Funding

National Research Foundation of Korea (NRF) RS-2024-00408466National Research Foundation of Korea (NRF) RS-2025-00557115
6 · The paper itself

Abstract

Mechanical properties of synthetic hydrogels remain inferior to those of load-bearing tissues such as ligaments, one of the strongest and stiffest natural hydrogels in the human body. Inspired by biological structures and their mechanisms conferring high mechanical properties, we report strong, stiff, and tough hydrogels composed of fiber-shaped elements that can be assembled into parallel bundles, closely resembling natural ligaments. These hydrogel fibers, readily fabricated with diameters of a few hundred micrometers, comprise polymer-particle hybrid agglomerates embedded in a continuous, interconnected polymer matrix. Strong polymer-particle interactions combined with spatial confinement within the agglomerates enable efficient load transfer, resulting in significant load-transfer lengths and substantial energy dissipation across the network. This design overcomes the conventional trade-offs between strength/stiffness and toughness/stretchability in polymer composites, thereby achieving tensile strength of 61 ± 8 MPa, elastic modulus of 131 ± 15 MPa, toughness 135 ± 11 MJ m

Identifiers

PMID41390679
PMCPMC12749280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.