Evidence map›Paper›PMID 41390652›Full record

ArticleJournal of nanobiotechnology2025

Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis.

Yuhe Jiang, Jianqi She, Zeying Wang, Yuan Zhu, Yunsong Liu, Ping Zhang, Hao Liu, Xiao Zhang, Yongsheng Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuhe JiangDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Jianqi SheDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Zeying WangDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Yuan ZhuDepartment of Stomatology, Peking University Third Hospital, Beijing, 100191, China.
Yunsong LiuDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Ping ZhangDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Hao LiuDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Xiao ZhangDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. kqxiaozhang@hsc.pku.edu.cn.
Yongsheng ZhouDepartment of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China. kqzhouysh@hsc.pku.edu.cn.

Funding

National Natural Science Foundation of China 82270954National Natural Science Foundation of China 82401060National Natural Science Foundation of China 824B2022Natural Science Foundation of Beijing Municipality 7222224postdoctoral fellowship program of CPSF GZC20230138
6 · The paper itself

Abstract

backgroundSenile bone-fat imbalance poses a significant public health burden in aging populations. This study investigates how aging affects the heterogeneity of mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) and develops a therapeutic strategy to rectify age-related bone-fat metabolic disorders.

resultsProtein cargo analysis revealed that MSC-derived apoVs undergo age-dependent compositional remodeling, with Thy1 identified as a key biomarker progressively declining with donor aging. Functional validation confirmed Thy1's critical role in mediating apoV osteoinductive and anti-adipogenic capacities. Engineered Thy1-enriched apoVs, produced through magnetic-activated sorting and protein corona technology, significantly enhanced osteogenesis and suppressed adipogenesis in recipient MSCs by activating the Thy1-ERK-TAZ signaling axis. In aged mouse models, these engineered apoVs restored trabecular bone mass, reduced marrow adipose tissue, and ameliorated systemic lipid metabolism disorders.

conclusionsThis work establishes Thy1 as a functional biomarker for aging-related apoV heterogeneity and demonstrates that engineered Thy1-enriched apoVs represent a clinically scalable therapeutic approach for senile bone-fat imbalance. The identified Thy1-ERK-TAZ mechanism provides a tunable platform for developing extracellular vesicle-based interventions against age-related metabolic diseases.

Indexed as

ApoptosisBone and BonesExtracellular VesiclesThy-1 AntigensAdipogenesisAdipose TissueAgingAnimalsHumansMaleMAP Kinase Signaling SystemMesenchymal Stem CellsMiceMice, Inbred C57BLOsteogenesisSignal TransductionThy-1 AntigensApoptotic vesiclesBone-fat imbalanceMesenchymal stem cellsSenileThy1

Identifiers

PMID41390652
PMCPMC12817589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.