Evidence map›Paper›PMID 41390612›Full record

SynthesisBMC cardiovascular disorders2025

Mortality after urgent versus elective transcatheter aortic valve replacement: a systematic review and meta-analysis using reconstructed individual patient data from Kaplan-Meier curves.

Mohammadreza Babaei, Parisa Fallahtafti, Negin Sadat Hosseini Mohammadi, Alireza Azarboo, Amirhossein Habibzadeh, Amirali Azizpour, Sina Rashedi, Jishanth Mattumpuram, Amr Mohsen, Zahra Hosseini and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohammadreza Babaei *Vascular Disease and Thrombosis Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Parisa Fallahtafti *Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Negin Sadat Hosseini MohammadiTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Alireza AzarbooTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Amirhossein HabibzadehSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Amirali AzizpourSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sina RashediThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jishanth MattumpuramDivision of Cardiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Amr MohsenDivision of Cardiology, Loma Linda University Medical Center, CA, Loma Linda, USA.
Zahra HosseiniCardiovascular Intervention Research Center, Rajaie Cardiovascular Institute, Tehran, Iran.
Hamidreza SoleimaniDepartment of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, 1419733141, Iran. hamid.r.soleimani90@gmail.com.
Dhaval KolteCardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrgent transcatheter aortic valve replacement (TAVR), performed during unplanned hospitalizations, is linked to worse outcomes compared with elective TAVR. However, temporal trends in mortality remains poorly understood. This study aimed to compare survival after urgent versus elective TAVR using a reconstructed individual patient data (IPD) meta-analysis.

methodsPubMed, Embase, and Scopus were searched through August 2025. Studies reporting Kaplan-Meier (KM) survival curves for urgent versus elective TAVR were included. Survival data were digitally extracted from published KM curves, and IPD were reconstructed algorithmically using a two-stage approach. Kaplan-Meier curves and Cox frailty models estimated survival and hazard ratios (HRs). Landmark analysis at one-year post-procedure and restricted mean survival time (RMST) were also employed to compare survival.

resultsEleven studies including 77,108 patients were identified. Kaplan-Meier curves were available for 76,108 patients (urgent: 5,683; elective: 71,425) and used for reconstructed IPD analysis. Urgent TAVR was associated with higher early mortality (HR 1.83, 95% CI: 1.73-1.93; p < 0.001), with convergence beyond one year (HR 1.01, 95% CI: 0.84-1.22; p = 0.83). RMST analysis demonstrated a 6.5-month overall survival advantage in favor of elective TAVR (p = 0.001).

conclusionsUrgent TAVR is associated with significantly increased early mortality compared with elective TAVR. These findings highlight the prognostic implications of procedural timing and support early referral for elective intervention in patients with severe AS.

Indexed as

Aortic ValveAortic Valve StenosisTranscatheter Aortic Valve ReplacementAgedAged, 80 and overElective Surgical ProceduresFemaleHumansKaplan-Meier EstimateMaleRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeAortic stenosisMortalitySurvival analysisTranscatheter aortic valve replacement

Identifiers

PMID41390612
PMCPMC12954897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.