Trial reportBMC gastroenterology2025
Combined water exchange and cap-assisted colonoscopy reduces cecal intubation time and patient discomfort in patients with unsedated colonoscopy: a randomized controlled trial.
Trial report in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Role of Computational Models in the Detection of Colorectal Carcinoma and Precancerous Lesions.International journal of molecular sciences · 2026Review
- Patient-reported outcomes and measures applied in individuals undergoing colonoscopy surveillance for colorectal cancer: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimColonoscopic insertion remains technically challenging. While cap-assisted colonoscopy (CAC) reduces the cecal intubation time (CIT), sigmoid colon water exchange (SWE) enhances linear scope advancement. We hypothesized that combined water exchange and cap-assisted colonoscopy (SWC) would optimize the CIT and improve patient tolerance during unsedated colonoscopy. PATIENTS AND
methodsThis prospective randomized controlled trial (RCT) included 200 subjects scheduled for unsedated colonoscopy at a tertiary endoscopy center in Wuhan, China. The participants were randomly assigned to receive either SWC (intervention, n=100) or CAC (control, n=100). The primary outcome was CIT (minutes). The secondary outcomes included pain scores, the polyp detection rate (PDR), bowel preparation quality (Boston Bowel Preparation Scale (BBPS)), and patient willingness to repeat the procedure.
resultsCompared with CAC, SWC significantly reduced the median CIT (5.0 [IQR 4.0-7.0] min vs. 7.0 [6.0-10.0] min; P < 0.001). The left colon pain scores were lower with SWC (1.0 [1.0-2.0] vs. 2.0 [1.0-3.0]; P < 0.001), and the willingness to repeat was greater (96.0% vs. 85.9%; P = 0.024). The PDRs (61.6% vs. 58.6%; P = 0.663) and BBPS scores (P = 0.213) were comparable. Multivariate analysis revealed that SWC, better bowel preparation, younger age, no prior abdominal surgery, and the absence of constipation were independent predictors of a shorter CIT.
conclusionSWC shortens the CIT, reduces discomfort, and improves patient acceptance without compromising procedural quality-advantages conducive to promoting and popularizing unsedated colonoscopy.
trial registrationThe registry titled "Transparent cap combined water exchange enteroscopy versus transparent cap method enteroscopy in time to cecal intubation: a prospective study"was registered in the Chinese Clinical Trial Registry on 14/05/2025 (clinical trial registration number: ChiCTR2500102387).Retrospectively registered.
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