Evidence map›Paper›PMID 41390586›Full record

ArticleAnalytical and bioanalytical chemistry2026

A microfluidic biomimetic system from the blood-brain barrier to activated microglia towards anti-Mesial Temporal Lobe Epilepsy drug screening.

Yunhua Wang, Meng Du, Zhanfei Xie, Huicheng Chen, Ling Lu, Lan Jiang, Lin Wang, Guoxia Zheng

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunhua Wang *Medical School, Dalian University, Dalian, 116622, China.
Meng Du *Department of Clinical Laboratory, Huaian Hospital of Huaian City, Huaian, 223200, Jiangsu, China.
Zhanfei XieEnvironmental and Chemical Engineering Institute, Dalian University, Dalian, 116622, China.
Huicheng ChenDepartment of Obstetrics and Reproductive Medicine, Affiliated Hospital of Yunnan University, Kunming, 650021, Yunnan, China.
Ling LuMedical School, Dalian University, Dalian, 116622, China.
Lan JiangKey Laboratory of Biophysics of Liaoning Province, Dalian, 116622, China.
Lin WangKey Laboratory of Biophysics of Liaoning Province, Dalian, 116622, China. Wanglin1@dlu.edu.cn.
Guoxia ZhengKey Laboratory of Biophysics of Liaoning Province, Dalian, 116622, China. Guoxiazheng2685@163.com.ORCID http://orcid.org/0000-0002-3494-8591

Funding

Interdisciplinary project of Dalian University DLUXK-2024-YB-003Interdisciplinary project of Dalian University DLUXK-2024-YB-008
6 · The paper itself

Abstract

The development of drugs for mesial temporal lobe epilepsy (mTLE) is hampered by the absence of preclinical models that can concurrently evaluate blood-brain barrier (BBB) penetration and target efficacy. To bridge critical gaps in preclinical screening, we developed an integrated microfluidic µBBB-(KA-MG)-mTLE chip that simultaneously models a perfusable human BBB under physiological shear stress (0.03-2.04 dyn/cm

Indexed as

AnticonvulsantsBiomimeticsBlood-Brain BarrierEpilepsy, Temporal LobeLab-On-A-Chip DevicesMicrogliaDrug Evaluation, PreclinicalHumansAnticonvulsantsAnti-mTLEBlood-brain barrierDrug screeningMicrofluidicsPermeability

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.