ArticleEuropean radiology2026
Thyroid incidentalomas detected on
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Letter to the Editor: Thyroid incidentalomas detected on 18F-fluorodeoxyglucose positron emission tomography with computed tomography in cancer patients: imaging clues for further evaluation.European radiology · 2026Article
- Reply to the Letter to the Editor: Thyroid incidentalomas detected onEuropean radiology · 2026Article
- Author's Reply.Sisli Etfal Hastanesi tip bulteni · 2026Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the malignancy risk of thyroid incidentalomas (TI) detected on MATERIALS AND
methodsAmong 71,878 patients who underwent
resultsThe malignancy rate of PET/CT-detected TI was 50.4% (118/234). Malignant nodules were associated with younger age (p = 0.03), smaller size (p < 0.001), higher SUVmax (p < 0.001), homogeneous density (p = 0.03), and irregular CT margins (p < 0.001). In multivariable analysis, smaller size (< 1.5 cm; odds ratio [OR], 2.65; 95% CI: 1.45-4.85; p = 0.001), irregular CT margin (OR, 3.04; 95% CI: 1.62-5.70; p = 0.001), and higher SUVmax (≥ 6.25; OR, 2.55; 95% CI: 1.44-4.52; p = 0.001) remained independent predictors of malignancy.
conclusionIn our retrospective cohort, the risk of malignancy in TI detected on ¹⁸F-FDG PET/CT increases with smaller nodule size, higher SUVmax, irregular CT margins, and younger patient age. Combining these imaging and clinical parameters improves malignancy prediction. In oncologic patients, selective ultrasound evaluation of such nodules may facilitate diagnosis while avoiding unnecessary procedures. KEY POINTS: Question Which clinical and imaging features predict malignancy in TI detected by 18F-FDG PET/CT in cancer patients? Findings Malignancy was associated with smaller nodule size (< 1.5 cm), higher SUVmax (≥ 6.25), and irregular margins on CT among 234 cases. Clinical relevance Cancer patients with metabolically active thyroid nodules showing irregular CT margins may benefit from selective ultrasound to enable early diagnosis and appropriate management.
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