Evidence map›Paper›PMID 41390555›Full record

ArticleAnnals of surgical oncology2026

Systematic Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Compared with Targeted EBUS-TBNA for Mediastinal Staging of Locally Advanced Non-small Cell Lung Cancer.

Víctor Fajardo, Bruno García-Cabo, Ramón Rami-Porta, Mireia Martínez-Palau, Bienvenido Barreiro, Lluís Esteban, Sergi Call, Juan Manuel Ochoa, Carme Obiols, Mireia Serra and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Víctor FajardoPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Bruno García-CaboPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Ramón Rami-PortaThoracic Surgery Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Mireia Martínez-PalauPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Bienvenido BarreiroPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Lluís EstebanPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Sergi CallThoracic Surgery Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Juan Manuel OchoaThoracic Surgery Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Carme ObiolsThoracic Surgery Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Mireia SerraThoracic Surgery Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
José Manuel GonzálezNuclear Medicine, Diagnostic Technology Center Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
Montserrat YsamatNuclear Medicine, Diagnostic Technology Center Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain.
José Sanz-SantosPulmonology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, Terrassa, Barcelona, Spain. jsanzsantos@ub.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe compared systematic endobronchial ultrasound-guided transbronchial needle aspiration (S-EBUS-TBNA) [sampling every lymph node (LN) > 5 mm regardless of its appearance on positron emission tomography/computed tomography (PET/CT)] with targeted (T) EBUS-TBNA (sampling only abnormal LNs on PET/CT) for mediastinal staging of locally advanced non-small cell lung cancer (NSCLC). PATIENTS AND

methodsPatients with NSCLC with N2 involvement on PET/CT who underwent S-EBUS-TBNA were retrospectively included. For T-EBUS-TBNA, the results of the samplings of abnormal PET/CT LNs during S-EBUS-TBNA were considered. The percentage of cases where S-EBUS-TBNA diagnosed a larger extent of mediastinal disease compared with T-EBUS-TBNA (upstaging from N2a to N2b/N3 and upstaging from N2b to N3) was estimated.

resultsA total of 89 patients were included: 61 had N2a and 28 had N2b on PET/CT. Of the 61 with N2a S-EBUS-TBNA diagnosed N3 disease in 2 cases, N2b in 4, N2a in 43, and N0/1 in 12. These 12 patients underwent video-assisted mediastinoscopy (VAM) that showed N2a involvement in 3 and N0/1 in 9. Of the 28 with N2b, S-EBUS-TBNA proved N3 disease in 2 cases, N2b in 10 cases, N2a in 7, and N0/1 in 9. These nine patients underwent confirmatory VAM that showed N2a in two and N0/1 in 7. S-EBUS-TBNA diagnosed a larger extent of mediastinal disease compared with T-EBUS-TBNA staging in 9% of cases: 4 patients with N3 disease that had N2 on PET/CT and four with N2b that had N2a on PET/CT.

conclusionsIn patients with NSCLC, S-EBUS-TBNA diagnoses a larger extent of mediastinal disease compared with T-EBUS-TBNA.

Indexed as

AdenocarcinomaCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellEndoscopic Ultrasound-Guided Fine Needle AspirationLung NeoplasmsLymph NodesMediastinal NeoplasmsAdultAgedAged, 80 and overBronchoscopyFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleEBUS-TBNALung cancerMediastinal stagingN2Video-assisted mediastinoscopy

Identifiers

PMID41390555

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.