Evidence map›Paper›PMID 41390517›Full record

ArticleNPJ science of food2025

The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue.

Shuai Wang, ShengLan Lin, Fuan Xie, Shuting Liu, Ting He, Kun Chen, Zhengrong Huang, Wenlong Xie, Hongqiu Cheng, Jian Zhang and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Shuai Wang *Department of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
ShengLan Lin *Department of Gerontology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Fuan Xie *Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, PR China.
Shuting LiuState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network and Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School oF Life Sciences, Xiamen university, Xiamen, Fujian, China.
Ting HeState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network and Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School oF Life Sciences, Xiamen university, Xiamen, Fujian, China.
Kun ChenState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network and Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School oF Life Sciences, Xiamen university, Xiamen, Fujian, China.
Zhengrong HuangDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wenlong XieState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network and Engineering Research Center of Molecular Diagnostics of the Ministry of Education, School oF Life Sciences, Xiamen university, Xiamen, Fujian, China.
Hongqiu ChengDepartment of Hepatology and Infectious Diseases, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, PR China.
Jian ZhangShandong Key Laboratory of Healthy Food Resources Exploration and Creation, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. 7210201081@stu.jiangnan.edu.cn.
Weihua LiDepartment of Cardiology, Xiamen Key Laboratory of Cardiac Electrophysiology, Xiamen Institute of Cardiovascular Diseases, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. liweihua@xmu.edu.cn.

Funding

National Natural Science Foundation of China 82170266Postdoctoral Fellowship Program of CPSF GZC20231412Postdoctoral Fellowship Program of CPSF GZC20240901Special Fund Project for Science and Technology of Guangdong Province 2020035Xiamen Municipal Bureau of Science and Technology 3502Z20224021Youth research project of Xiamen Health High-quality Development Science and Technology Plan in 2024 2024GZL-QN032
6 · The paper itself

Abstract

Amid growing global concerns over obesity, the identification of novel lipid resources with potential health benefits has become a key focus in food science. Artemisia argyi, a traditional edible plant, is valued for its bioactive volatile oils, yet the effects of Artemisia argyi oil (AAO) on lipid metabolism and energy balance remain largely unexplored. Brown adipose tissue (BAT), which facilitates energy dissipation via non-shivering thermogenesis, is a key target for dietary strategies to combat obesity. Here, we demonstrate that AAO combats obesity by promoting BAT thermogenesis, resulting in significant reductions in weight gain, body fat, and improved insulin sensitivity. Mechanistically, AAO promotes Ucp1 transcription by directly activating ZFP516 expression and enhancing its interaction with LSD1. These findings identify AAO as a natural dietary component with potential to improve metabolic health through BAT activation, offering insights for its use in functional foods aimed at energy balance and weight management.

Identifiers

PMID41390517
PMCPMC12749911

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.