ArticleNPJ science of food2025
Meta-analysis of extremotolerant microbes to address nutrient deficiencies in bioregenerative life support systems during Deep-space Missions.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Genome sequence of the stress-tolerant yeastMicrobiology resource announcements · 2026Article
- Integrating resource utilization and bioregenerative life support systems for sustainable space exploration.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ensuring adequate nutrition is essential for long-duration space missions where Earth resupply is limited or unfeasible. Bioregenerative Life Support Systems (BLSS), such as ESA's MELiSSA, aim to sustain astronauts by recycling resources and cultivating crops. However, plant-based diets in BLSS may lack key micronutrients. This study identified nutritional gaps in crop-based BLSS diets, revealing deficiencies in several micronutrients, including cobalamin (vit B₁₂), riboflavin (vit B₂), and calciferol (vit D). We screened microorganisms for genomic potential to produce these micronutrients and filtered candidates based on inclusion in the EFSA Qualified Presumption of Safety and Novel Food lists. Organisms were prioritized based on biosynthetic capability and robustness. The result is a ranked list of microbial candidates capable of addressing nutritional deficiencies in BLSS diets. These findings support the integration of resilient, nutrient-producing microbes into space food systems, offering a strategic path toward self-sufficient and health-supportive nutrition for future deep space missions.
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Registered trials
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