Evidence map›Paper›PMID 41390395›Full record

ArticleBMC cancer2025

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.

Xun Yang, Yidi Wu, Qingxin Zhang, Yunfei Zhou, Shuyuan Chang, Chunhui Zhang, Dabin Liu

Abstract read
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In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xun Yang *NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China.
Yidi Wu *NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China.
Qingxin Zhang *NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China.
Yunfei ZhouNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China.
Shuyuan ChangNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China.
Chunhui ZhangDepartment of Student Affairs, The Fourth Hospital of Harbin Medical University, Harbin, China. 1280289406@qq.com.
Dabin LiuNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, The Fourth Hospital of Harbin Medical University, Harbin, China. liudb526@hrbmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains indistinct. In this study, multi-omics data were employed to identify ferroptosis-associated genes linked to SQLE in HCC, which were subsequently categorised into two prognostic risk categories. Kaplan-Meier analysis revealed patients allocated to the high-risk group exhibiting markedly poorer outcomes compared to those in the low-risk group, thereby underscoring the independent prognostic value of the ferroptosis-related prognostic signature in HCC. Furthermore, MTT assays further demonstrated that overexpression of SQLE conferred resistance to the ferroptosis inhibitor Fer-1 in cancer cells, while reduced expression of SQLE augmented cellular susceptibility to ferroptosis. Additionally, the expression levels of SQLE were found to positively correlate with the ferroptosis inhibitor gene PARP2. Knockdown of PARP2 significantly mitigated SQLE-induced cholesterol accumulation and cellular proliferation. This study illustrates the role of SQLE as a ferroptosis inhibitor in HCC, offering novel insights into the prognostic evaluation and molecular mechanisms underlying HCC.

Indexed as

Carcinoma, HepatocellularFerroptosisLiver NeoplasmsSqualene MonooxygenaseCell Line, TumorCell ProliferationCohort StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisSqualene MonooxygenaseFerroptosisHepatocellular carcinomaPARP2SQLE

Identifiers

PMID41390395
PMCPMC12817838

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.