Evidence map›Paper›PMID 41390390›Full record

ArticleBMC pulmonary medicine2025

Association between menopausal age and chronic obstructive pulmonary disease and the mediating role of smoking: a study based on NHANES 1999-2018.

Tianye Li, Hongjun Zhao, Hao Xu, Mengya Yang, Yanhong Zheng, Chengshui Chen, Beibei Wang

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Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tianye Li *Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Hongjun Zhao *Zhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Clinical Research Center, Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, China.
Hao XuZhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Clinical Research Center, Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, China.
Mengya YangZhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Clinical Research Center, Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, China.
Yanhong ZhengZhejiang Province Engineering Research Center for Endoscope Instruments and Technology Development, Clinical Research Center, Department of Pulmonary and Critical Care Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, 324000, China.
Chengshui ChenKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. chenchengshui@wmu.edu.cn.
Beibei WangKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. wangbeibei@wmu.edu.cn.

Funding

Health Industry Scientific Research Project of Gansu Province grants GSWSKY2018-18National Key Research and Development Program of China grants 2016YFC1304000National Natural Scientific Foundation of China 82170017Zhejiang Provincial Key Research and Development Program 2020C03067
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, with smoking as its primary risk factor. The relationship between menopausal age and COPD remains unknown. This study examines this potential association.

methodsUsing NHANES 1999–2018 data, we analyzed associations between menopausal age and COPD via weighted logistic regression, weighted linear regression, restricted cubic spline (RCS) analysis, and explored the potential mediating role of smoking.

resultsThis study included a total of 8,731 participants. Every year increase in menopausal age was associated with a 1.2% reduction in COPD risk after completely adjusting the Model (odds ratio [OR] = 0.988, 95% confidence interval [CI]: 0.979–0.998, P < 0.001). After grouping participants based on tertiles of menopausal age, COPD risks decreased by 19.0% in the T2 (OR = 0.810, 95% CI: 0.662–0.991, P = 0.040) and 21.4% in the T3 (OR = 0.786, 95% CI: 0.644–0.958, P = 0.018) relative to T1, respectively. RCS regression uncovered a linear association between menopausal age and COPD risk (P-overall < 0.001, P-nonlinear = 0.080). Subgroup analysis demonstrated that menopausal age was inversely related to COPD risk in general populations. Mediation analysis suggested that smoking partially mediated (38.0%) the link between menopausal age and COPD.

conclusionLater age at menopause is significantly associated with a reduced risk of COPD, and smoking may partially explain this association. These findings suggest the potential value of targeted screening and highlight the importance of smoking cessation interventions in this population.

Indexed as

MenopausePulmonary Disease, Chronic ObstructiveSmokingAdultAgedAge FactorsFemaleHumansLogistic ModelsMiddle AgedNutrition SurveysRisk FactorsUnited StatesCOPDMediation analysisMenopausal ageNHANESSmoking

Identifiers

PMID41390390
PMCPMC13067747

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.