Observational studyBMC anesthesiology2025
Incidence and risk factors of post-intensive care syndrome (PICS) in sepsis survivors: a prospective, observational study.
Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Clinical Features and 1-Year Prognosis of Patients with Suspected Sepsis and Positive Blood Cultures in the Emergency Department: A Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPost-intensive care syndrome (PICS) encompasses new or worsening impairments in physical, cognitive, or mental health that manifest and persist after critical illness, yet the burden of PICS in this population remains under-characterized. We sought to quantify the incidence of PICS in sepsis survivors and to identify its independent predictors.
methodsWe conducted a prospective observational study of adult sepsis patients discharged from the medical ICU of Jinling Hospital, Nanjing University School of Medicine, between October 2024 and February 2025. Comprehensive baseline data-including demographics, clinical characteristics, and ICU interventions-were collected. Standardized telephone and in-person assessments were performed at 1, 3, and 6 months post-discharge to diagnose PICS across physical, cognitive, and mental health domains. Multivariate logistic regression was used to determine risk factors associated with incident PICS.
resultsOf 238 eligible patients, 150 met all inclusion criteria and completed follow-up assessment. The incidence of PICS was 72% at 1 month, 68% at 3 months, and 44% at 6 months. Multi-domain impairment (≥ 2 domains) was present in 38%, 34%, and 20% of survivors at the same timepoints, respectively; concurrent impairment in all three domains declined from 10.7% to 0.7%. After adjustment, higher APACHE II scores (OR = 1.57, 95% CI 1.27-1.94, P < 0.001) and elevated peak blood glucose (OR = 2.23, 95% CI 1.54-3.23, P < 0.001) independently predicted PICS, whereas higher education level (OR = 0.66, 95% CI 0.53-0.82, P < 0.001) conferred protection.
conclusionsPICS is common among sepsis survivors, with incidence declining but remaining substantial up to 6 months after ICU discharge. APACHE II scores and glycaemic control are robust, modifiable predictors, while educational attainment appears protective.
trial registrationRegistered in the Chinese Clinical Trial Registry ChiCTR2400094977 (Date: 31/12/2024).
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