ArticleWorld journal of pediatrics : WJP2026
Final height prediction of girls at menarche: a combined model using left hand and wrist bone age, knee radiomic scores, and clinical characteristics.
Article in World journal of pediatrics : WJP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reproductive experience promotes permanent body growth independently of growth hormone.bioRxiv : the preprint server for biology · 2026Article
- Discordance among skeletal maturity indicators: sources, interpretation, and clinical implications.Frontiers in pediatrics · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundAccurate final height prediction for girls with menarche is important, yet traditional Greulich-Pyle (GP) and Bayley-Pinneau predictions based on left hand-wrist bone age (BA) and target height demonstrate limited accuracy. This study aims to develop a method to more accurately predict final height.
methodsOne hundred and seventy-three girls with menarche from August 2018 to June 2023 were analyzed retrospectively. BAs in Greulich and Pyle and Hoerr knee atlases were evaluated. Knee radiomic features were extracted using PyRadiomics; least absolute shrinkage and selection operator regression was utilized to develop radiomic scores of the distal femur and proximal tibia. Ordinary least squares regression with stepwise selection was used to build a multilinear equation. This was further compared with traditional methods in fivefold cross-validation (CV = 5) using residual distribution and Bland-Altman agreement analysis.
resultsHeight gain in our Chinese cohort after menarche was 8.94 ± 2.99 cm. A stepwise multilinear equation was built with height at menarche, BA of GP and radiomic score of the distal femur (R
conclusionsA robust linear regression model that incorporates knee radiomic scores, BA of GP, height at menarche, and father's height demonstrated the best final height prediction in our cohort. This research is an innovative application of radiomic score of the distal femur to final height prediction. Further validation is warranted to test robustness across populations and scenarios.
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