Evidence map›Paper›PMID 41390117›Full record

ArticleJournal of advanced research2026

Essential function of Nr4a2 in subicular development and social novelty.

Xi-Yue Liu, Yun-Chao Tao, Qiong Zhang, Wei-Tang Liu, Li Zhao, Zhi-Bin Hu, Bing-Yao Zhou, Ze-Xuan Li, Cong-Cong Qi, Lei Zhang and 3 more

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Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xi-Yue LiuState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Yun-Chao TaoState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Qiong ZhangLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China.
Wei-Tang LiuLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
Li ZhaoState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Zhi-Bin HuLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China.
Bing-Yao ZhouState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Ze-Xuan LiLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China.
Cong-Cong QiLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China.
Lei ZhangShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai 200092, China; Clinical Center for Brain and Spinal Cord Research, Tongji University, Shanghai 200092, China.
Jia-Yin ChenLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China.
Ning-Ning SongLaboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China. Electronic address: songnn@fudan.edu.cn.
Yu-Qiang DingState Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; Laboratory Animal Center and MOE Mouse Resource Center, Fudan University, Shanghai 200032, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China; Huashan Institute of Medicine (HS-IOM), Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: dingyuqiang@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe subicular regions are a major output hub of the hippocampus. Recent studies have shown that subicular neurons are highly diverse in their gene expression patterns, neural circuitry, and electrophysiological properties. However, the developmental transcriptional program underlying their specification remains poorly understood.

objectivesTo delineate how the orphan nuclear receptor Nr4a2 orchestrates both the developmental specification and functional maintenance of subicular neurons, and to uncover the underlying molecular mechanisms.

methodsNr4a2 conditional knockout (CKO) mice and adult subicular-specific AAV-Nr4a2 CKO mice were comprehensively profiled using RNA-seq, CUT&Tag, immunohistochemistry, slice electrophysiology, and behavioural assays to elucidate the developmental and functional sequelae of Nr4a2 ablation.

resultsIn this study, using conditional genetic models targeting the orphan nuclear receptor Nr4a2, we demonstrate that Nr4a2 is essential for both the acquisition and maintenance of the molecular identity of subiculum proper (Sub) neurons, as well as for establishing its connectivity with the retrosplenial cortex (Rsp) during embryonic development and adulthood. Loss of Nr4a2 in subicular regions results in deficits in social novelty in mice. Furthermore, we show that Nr4a2 can directly bind to the promoters of Sub-enriched genes and promote their transcription in vivo.

conclusionTogether, these findings reveal a pivotal role for Nr4a2 in establishing the genetic identity and connectivity of Sub neurons and suggest that its dysfunction may contribute to hippocampus-related neurodevelopmental disorders.

Indexed as

HippocampusNuclear Receptor Subfamily 4, Group A, Member 2Social BehaviorAnimalsMaleMiceMice, KnockoutNeurodevelopmentNeuronsNr4a2 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 2Nr4a2Retrosplenial cortexSocial noveltySubiculum proper

Identifiers

PMID41390117
PMCPMC13539151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.