Evidence map›Paper›PMID 41390116›Full record

ArticleJournal of advanced research2026

RNA m

Hanxue Zheng, Du Wang, Linfeng Li, Qian Xu, Mengdi Cheng, Jiayi Chen, Siyi Zhu, Duan Lin, Ruohan Lin, Wenjuan Xue and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanxue ZhengLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Du WangLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Linfeng LiLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Qian XuLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Mengdi ChengLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Jiayi ChenLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Siyi ZhuLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Duan LinLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Ruohan LinLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Wenjuan XueLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Shiyue LiuLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Gerui QuLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China.
Yuan YuLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an 710069 Shaanxi, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069 Shaanxi, China. Electronic address: yuyuan@nwu.edu.cn.
Fulin ChenLaboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069 Shaanxi, China; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an 710069 Shaanxi, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069 Shaanxi, China. Electronic address: chenfl@nwu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPlanarians exhibit remarkable notable regenerative capacity, through the self-renewal of the neoblast stem cells. The RNA N

objectivesThis study was aimed at investigating the role of DjYTHDF2.2 in regulating neoblast self-renewal and regeneration in planarians and identifying its functional targets and underlying mechanisms.

methodsThe spatiotemporal expression of Djythdf2.2 was analyzed via quantitative reverse-transcription PCR and whole-mount in situ hybridization. Djythdf2.2 function in tissue homeostasis and regeneration was assessed through RNA interference (RNAi) and immunostaining. MeRIP-seq and RNA-seq were used to identify m

resultsDjythdf2.2 showed pronounced upregulation after amputation. Its knockdown severely impaired tissue homeostasis and regeneration by suppressing neoblast proliferation. Integrated methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA-seq identified the metalloendopeptidase gene Djastacin (Djast) as a key m

conclusionThese findings show that DjYTHDF2.2 promotes neoblast self-renewal and regeneration by targeting Djast mRNA for degradation, which is a novel m

Indexed as

PlanariansRegenerationRNA-Binding ProteinsAdenosineAnimalsCell ProliferationRNA InterferenceRNA, MessengerRNA MethylationSignal TransductionAdenosineRNA-Binding ProteinsRNA, MessengerASTM(6)ANeoblastsPlanarian regenerationYTHDF2

Identifiers

PMID41390116
PMCPMC13539150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.