Observational studyOsteoarthritis and cartilage2026
Immediate reductions in compressive and shear forces in the knee from gait retraining are associated with slowed cartilage degeneration after 1 year in medial knee osteoarthritis: A retrospective observational cohort study.
Observational study in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Sagittal alignment and patellofemoral consequences of open wedge high tibial osteotomy: a comparative radiological and gait analysis of supratubercle and distal tibial tuberosity techniques.Journal of orthopaedic surgery and research · 2026Article
- A biomechanical digital twin of Legg-Calvé-Perthes disease deformity.International journal of computer assisted radiology and surgery · 2026Article
- Foot progression angle modifications alter hip joint contact forces and femoral growth plate mechanics in children.Frontiers in bioengineering and biotechnology · 2026Article
- From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo identify which immediate changes in knee loading from a gait modification relate to changes in cartilage microstructure after one year.
methodThis was a one-year retrospective observational cohort study of twenty-five participants with medial knee osteoarthritis who walked with a personalized gait modification that reduced their peak knee adduction moment by modifying their foot progression angle. Musculoskeletal modeling was used to estimate knee loading changes in response to the gait modification at the initial timepoint. Magnetic resonance imaging (MRI) was conducted at baseline and after one year of gait modification to assess the change in T
resultsCCA revealed that changes in cartilage microstructure were significantly correlated to knee loading metrics (r=0.84, 95% CI: 0.66-0.93, p<0.0001). Reductions in peak anteroposterior shear force (r=0.43, 95% CI: 0.05-0.71, p=0.03) and vertical force (r=0.42, 95% CI: 0.03-0.70, p=0.04) in the medial compartment during late-stance relate to reductions in the T
conclusionsBaseline and immediate changes in knee loading metrics during the initial adoption of a gait modification are associated with improvements in MRI-estimated measures of cartilage microstructure after one year of gait retraining. Knee contact force metrics may be more associated with cartilage health than knee moments, which currently serve as biomechanical targets for interventions. Compressive and shear forces should be explored as targets for load-reducing interventions for medial knee osteoarthritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.