Evidence map›Paper›PMID 41389858›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2026

Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging.

Trey Waldrop, Grace Murley, Brett Velasquez, Elise Konradsson, Denae Neill, Luke Connell, Alan Lopez Hernandez, Abagail Delahoussaye, F William Schuler, Jorge De La Cerda and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Trey WaldropDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: twaldrop@mdanderson.org.
Grace MurleyThe University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Department of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: gisakson@mdanderson.org.
Brett VelasquezDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Elise KonradssonDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Denae NeillDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Luke ConnellDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Alan Lopez HernandezDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Abagail DelahoussayeDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
F William SchulerDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Jorge De La CerdaDepartment of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Ziyi LiThe University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Department of Biostatistics, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: zli16@mdanderson.org.
Mark D PagelThe University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Department of Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: mdpagel2@wisc.edu.
Emil SchülerDepartment of Radiation Physics, UT MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: eschueler@mdanderson.org.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevanceR01CA266673 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SCHUELER, EMIL · 2022 to 2025
$3.5M
CTSA Predoctoral T32 at the University of Texas Health Science Center at HoustonT32TR004905 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Joya Chandra, Jeffrey A. Frost · 2024 to 2026
$811k
NCATS NIH HHS T32 TR004905NCATS NIH HHS TL1 TR003169NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA266673
6 · The paper itself

Abstract

purposeThe FLASH effect occurs when radiation given at ultra-high dose rates spares healthy tissue while achieving isoeffective tumor control relative to conventional (CONV) dose rate irradiation. Limited data has implicated oxygen in the FLASH effect. This study investigated the effect of tissue oxygen tension (pO

methodspO

resultsEPRI-measured pO

conclusionsOur findings demonstrate that both CONV- and FLASH-induced GI toxicity correlate with in-vivo oxygen tension and that age-matched male and female mice differ in FLASH radiosensitivity across the breathing-gas conditions examined.

Indexed as

Gastrointestinal TractOxygenAnimalsElectron Spin Resonance SpectroscopyFemaleKidneyLiverMaleMiceMice, Inbred C57BLOximetryOxygenElectron Paramagnetic Resonance ImagingFLASHGastrointestinal toxicityIn-vivo oximetrySex differences

Identifiers

PMID41389858
PMCPMC12747515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.